Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation
Cui W, Bai Y, Miao X, Luo P, Chen Q, Tan Y, Rane MJ, Miao L, Cai L
Oxidative medicine and cellular longevity · 104 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Diabetes Association
- Universidad u hospital
- Wenzhou Medical College
- Subvenciones
- Wenzhou Medical College (1-11-BA-0117); American Diabetes Association (1-11-BA-0117)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2012-01-01 · Oxid Med Cell Longev · vol. 2012 · págs. 1–12
- Editorial
- Hindawi Publishing Corporation
- Citado
- 141 citas · más que el 96% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Biochemical Acid Research Studies · Chemotherapy-induced organ toxicity mitigation
- Palabras clave
- Sulforaphane, Diabetic nephropathy, Diabetes mellitus, Medicine, Streptozotocin, Downregulation and upregulation, Endocrinology, Nephropathy, Internal medicine, Oxidative stress, Kidney, Fibrosis, Cancer research, Chemistry, Biochemistry
- MeSH
- cell line, animals, humans, mice, diabetic nephropathies, diabetes mellitus, experimental, disease models, animal, mannitol, thiocyanates, isothiocyanates, sulfoxides, nad(p)h dehydrogenase (quinone), catalase, superoxide dismutase, glucose, palmitates, rna, small interfering, anticarcinogenic agents, rna interference, up-regulation, oxidative stress, male, nf-e2-related factor 2, heme oxygenase-1
9 autores
- Wenpeng Cui🇺🇸🇨🇳University of Louisville; Second Affiliated Hospital of Jilin University; Baxter (United States)
- Yang Bai🇺🇸🇨🇳University of Louisville; People 's Hospital of Jilin Province; Baxter (United States)
- Xiao Miao🇺🇸🇨🇳University of Louisville; Second Affiliated Hospital of Jilin University; Baxter (United States)
- Ping Luo🇨🇳Second Affiliated Hospital of Jilin University
- Qiang Chen🇺🇸🇨🇳University of Louisville; Jilin University; Baxter (United States)
- Yi Tan🇺🇸🇨🇳University of Louisville; Wenzhou Medical University; Baxter (United States)
- Madhavi J. Rane🇺🇸University of Louisville
- Lining Miao🇨🇳 · autor de correspondenciaSecond Affiliated Hospital of Jilin University
- Lu Cai🇺🇸🇨🇳 · autor de correspondenciaUniversity of Louisville; Wenzhou Medical University; Baxter (United States)
Resumen
El texto original del estudio, en el idioma en que se publicó.
The present study was to investigate whether sulforaphane (SFN) can prevent diabetic nephropathy in type 1 diabetic mouse model induced by multiple low-dose streptozotocin. Diabetic and age-matched control mice were given SFN at 0.5 mg/kg body weight daily for 3 months. At the end of 3-month SFN treatment, the diabetic nephropathy, shown by renal inflammation, oxidative damage, fibrosis, and dysfunction, was significantly prevented along with an elevation of renal Nrf2 expression and transcription in diabetes/SFN group compared with diabetic group. However, this renal prevention by SFN was not seen when the 3-month SFN-treated diabetic mice were aged for additional 3 months without further SFN treatment. Nrf2-mediated renal protective effects in diabetes were evaluated in human renal tubular HK11 cells transfected with control and Nrf2 siRNA and treated with 27.5 mM mannitol or high glucose plus palmitate (300 μM). Blockade of Nrf2 expression completely abolished SFN prevention of the profibrotic effect induced by high glucose plus palmitate. These results support that renal Nrf2 expression and its transcription play important roles in SFN prevention of diabetes-induced renal damage. However, the SFN preventive effect on diabetes-induced renal pathogeneses is not sustained, suggesting the requirement of continual use of SFN for its sustained effect.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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