Omega 3 Fatty acids and cardiovascular outcomes: systematic review and meta-analysis
Kotwal S, Jun M, Sullivan D, Perkovic V, Neal B
Circulation. Cardiovascular quality and outcomes · 144 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-10-31 · Circ Cardiovasc Qual Outcomes · vol. 5 · número 6 · págs. 808–818
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 202 citas · más que el 100% de estudios similares · 20.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, cardiovascular outcomes, cardiovascular mortality, myocardial infarction, stroke, vascular death, cardiac arrhythmias, cerebrovascular events, coronary revascularization, heart failure, end-stage renal disease, gastrointestinal adverse effects, dietary supplements, omega-3 supplementation
- MeSH
- humans, cardiovascular diseases, fatty acids, omega-3, cardiovascular agents, treatment outcome, odds ratio, evidence-based medicine, dietary supplements, aged, middle aged, female, male
5 autores
- Sradha S. Kotwal🇦🇺The University of Sydney; The George Institute for Global Health
- Min Jun🇦🇺The University of Sydney; The George Institute for Global Health
- DAVID R. SULLIVAN🇦🇺The University of Sydney; The George Institute for Global Health
- Vlado Perkovic🇦🇺The University of Sydney; The George Institute for Global Health
- Bruce Charles Neal🇦🇺The University of Sydney; The George Institute for Global Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Early trials evaluating the effect of omega 3 fatty acids (ω-3 FA) reported benefits for mortality and cardiovascular events but recent larger studies trials have variable findings. We assessed the effects of ω-3 FA on cardiovascular and other important clinical outcomes.
Methods and results
We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for all randomized studies using dietary supplements, dietary interventions, or both. The primary outcome was a composite of cardiovascular events (mostly myocardial infarction, stroke, and cardiovascular death). Secondary outcomes were arrhythmia, cerebrovascular events, hemorrhagic stroke, ischemic stroke, coronary revascularization, heart failure, total mortality, nonvascular mortality, and end-stage kidney disease. Twenty studies including 63030 participants were included. There was no overall effect of ω-3 FA on composite cardiovascular events (relative risk [RR]=0.96; 95% confidence interval [CI], 0.90-1.03; P=0.24) or on total mortality (RR=0.95; 95% CI, 0.86-1.04; P=0.28). ω-3 FA did protect against vascular death (RR=0.86; 95% CI, 0.75-0.99; P=0.03) but not coronary events (RR=0.86; 95% CI, 0.67-1.11; P=0.24). There was no effect on arrhythmia (RR=0.99; 95% CI, 0.85-1.16; P=0.92) or cerebrovascular events (RR=1.03; 95% CI, 0.92-1.16; P=0.59). Adverse events were more common in the treatment group than the placebo group (RR=1.18, 95% CI, 1.02-1.37; P=0.03), predominantly because of an excess of gastrointestinal side effects.
Conclusions
ω-3 FA may protect against vascular disease, but the evidence is not clear-cut, and any benefits are almost certainly not as great as previously believed.
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