Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis
Chowdhury R, Stevens S, Gorman D, Pan A, Warnakula S, Chowdhury S, Ward H, Johnson L, Crowe F, Hu FB, Franco OH
BMJ (Clinical research ed.) · 239 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-10-30 · BMJ · vol. 345 · número oct30 3 · pág. e6698
- Citado
- 380 citas · más que el 99% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Aquaculture Nutrition and Growth
- Palabras clave
- fish consumption, n-3 long-chain polyunsaturated fatty acids, cerebrovascular disease, ischemic stroke, hemorrhagic stroke, omega-3 supplementation, primary prevention, secondary prevention, dietary intake, circulating biomarkers, cardiovascular risk, transient ischemic attack, stroke
- MeSH
- animals, fishes, humans, cerebrovascular disorders, fatty acids, omega-3, diet, risk factors, prospective studies, dietary supplements, randomized controlled trials as topic
11 autores
- Rajiv Chowdhury🇬🇧University of Cambridge
- Sarah C. W. Stevens
- Donal N. Gorman🇬🇧University of Cambridge
- An Pan🇺🇸Harvard University
- Samantha Warnakula🇬🇧University of Cambridge
- S. Chowdhury
- Heather A Ward🇬🇧Imperial College London
- Laura Johnson🇬🇧University of Cambridge
- Francesca L. Crowe🇬🇧University of Oxford
- F. B. Hu🇺🇸Harvard University
- Oscar H. Franco🇬🇧🇳🇱 · autor de correspondenciaUniversity of Cambridge; Erasmus MC
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To clarify associations of fish consumption and long chain omega 3 fatty acids with risk of cerebrovascular disease for primary and secondary prevention.
Design
Systematic review and meta-analysis.
Data sources
Studies published before September 2012 identified through electronic searches using Medline, Embase, BIOSIS, and Science Citation Index databases.
Eligibility criteria
Prospective cohort studies and randomised controlled trials reporting on associations of fish consumption and long chain omega 3 fatty acids (based on dietary self report), omega 3 fatty acids biomarkers, or supplementations with cerebrovascular disease (defined as any fatal or non-fatal ischaemic stroke, haemorrhagic stroke, cerebrovascular accident, or transient ischaemic attack). Both primary and secondary prevention studies (comprising participants with or without cardiovascular disease at baseline) were eligible.
Results
26 prospective cohort studies and 12 randomised controlled trials with aggregate data on 794,000 non-overlapping people and 34,817 cerebrovascular outcomes were included. In cohort studies comparing categories of fish intake the pooled relative risk for cerebrovascular disease for 2-4 servings a week versus ≤ 1 servings a week was 0.94 (95% confidence intervals 0.90 to 0.98) and for ≥ 5 servings a week versus 1 serving a week was 0.88 (0.81 to 0.96). The relative risk for cerebrovascular disease comparing the top thirds of baseline long chain omega 3 fatty acids with the bottom thirds for circulating biomarkers was 1.04 (0.90 to 1.20) and for dietary exposures was 0.90 (0.80 to 1.01). In the randomised controlled trials the relative risk for cerebrovascular disease in the long chain omega 3 supplement compared with the control group in primary prevention trials was 0.98 (0.89 to 1.08) and in secondary prevention trials was 1.17 (0.99 to 1.38). For fish or omega 3 fatty acids the estimates for ischaemic and haemorrhagic cerebrovascular events were broadly similar. Evidence was lacking of heterogeneity and publication bias across studies or within subgroups.
Conclusions
Available observational data indicate moderate, inverse associations of fish consumption and long chain omega 3 fatty acids with cerebrovascular risk. Long chain omega 3 fatty acids measured as circulating biomarkers in observational studies or supplements in primary and secondary prevention trials were not associated with cerebrovascular disease. The beneficial effect of fish intake on cerebrovascular risk is likely to be mediated through the interplay of a wide range of nutrients abundant in fish.
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