Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies
Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K, Lundqvist A, Jassal SK, Barrett-Connor E, Zhang C, Eaton CB, May HT, Anderson JL, Sesso HD
Circulation. Cardiovascular quality and outcomes · 473 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIAMS NIH HHS
- Gobierno
- Intramural NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- NIA NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01AR45614); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01-AR45632); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AR45647); National Cancer Institute (U01CA138962); National Cancer Institute (CA138962); National Heart, Lung, and Blood Institute (R01-HL034594); National Institute of Diabetes and Digestive and Kidney Diseases (L30 DK084809); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AR-45583); National Center for Advancing Translational Sciences (UL1TR000128); National Institute on Aging (U01-AG-18197); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01-AR-45654); National Heart, Lung, and Blood Institute (K99 HL095649); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK088078); National Institute on Aging (U01 AG027810); National Heart, Lung, and Blood Institute (R01HL102122); National Heart, Lung, and Blood Institute (HL34594); National Center for Research Resources (UL 1RR024140); National Heart, Lung, and Blood Institute (R00HL095649); National Cancer Institute (R01CA138962); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01AR45580)
Según 16 financiadores declarados.
Publicación
- Publicado
- 2012-11-01 · Circ Cardiovasc Qual Outcomes · vol. 5 · número 6 · págs. 819–829
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 620 citas · más que el 100% de estudios similares · 37.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Parathyroid Disorders and Treatments
- Palabras clave
- 25-hydroxyvitamin D, vitamin D status, cardiovascular disease, cardiovascular mortality, coronary artery disease, stroke, dose-response relationship, vitamin D deficiency, circulating biomarkers
- MeSH
- humans, cardiovascular diseases, vitamin d deficiency, vitamin d, prognosis, linear models, odds ratio, risk assessment, risk factors, prospective studies, biomarkers
14 autores
- Lu Wang🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Yiqing Song🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- JoAnn E. Manson🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Stefan Pilz🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Winfried März🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Karl Michaëlsson🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Annamari Lundqvist🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Simerjot Kaur Jassal🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Elizabeth Barrett‐Connor🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Cuilin Zhang🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Charles B. Eaton🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Heidi Thomas May🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Jeffrey L. Anderson🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
- Howard D. Sesso🇺🇸🇦🇹Brigham and Women's Hospital; Harvard University; Medical University of Graz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear.
Methods and results
We searched MEDLINE and EMBASE from 1966 through February 2012 for prospective studies that assessed the association of 25(OH)-vitamin D concentrations with CVD risk. A total of 24 articles met our inclusion criteria, from which 19 independent studies with 6123 CVD cases in 65 994 participants were included for a meta-analysis. In a comparison of the lowest with the highest 25(OH)-vitamin D categories, the pooled relative risk was 1.52 (95% confidence interval, 1.30-1.77) for total CVD, 1.42 (95% confidence interval, 1.19-1.71) for CVD mortality, 1.38 (95% confidence interval, 1.21-1.57) for coronary heart disease, and 1.64 (95% confidence interval, 1.27-2.10) for stroke. These associations remained strong and significant when analyses were limited to studies that excluded participants with baseline CVD and were better controlled for season and confounding. We used a fractional polynomial spline regression analysis to assess the linearity of dose-response association between continuous 25(OH)-vitamin D and CVD risk. The CVD risk increased monotonically across decreasing 25(OH)-vitamin D below ≈60 nmol/L, with a relative risk of 1.03 (95% confidence interval, 1.00-1.06) per 25-nmol/L decrement in 25(OH)-vitamin D.
Conclusions
This meta-analysis demonstrated a generally linear, inverse association between circulating 25(OH)-vitamin D ranging from 20 to 60 nmol/L and risk of CVD. Further research is needed to clarify the association of 25(OH)-vitamin D higher than 60 nmol/L with CVD risk and assess causality of the observed associations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.