Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement
Al-Hilal M, Alsaleh A, Maniou Z, Lewis FJ, Hall WL, Sanders TA, O'Dell SD, MARINA study team
Journal of lipid research · 83 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-11-17 · J Lipid Res · vol. 54 · número 2 · págs. 542–551
- Editorial
- Elsevier BV
- Citado
- 98 citas · más que el 92% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Nutrition, Genetics, and Disease · Genetic Associations and Epidemiology
- Palabras clave
- delta-5 desaturase, delta-6 desaturase, long-chain polyunsaturated fatty acids, fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, single nucleotide polymorphisms, haplotype association, genetic variation, desaturase activity, gene-diet interaction
- MeSH
- erythrocytes, humans, fatty acid desaturases, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, unsaturated, fish oils, gene frequency, haplotypes, dietary supplements, middle aged, female, male, genetic loci, delta-5 fatty acid desaturase
7 autores
- Maryam Al‐Hilal🇬🇧King's College London
- Aseel Fuad Fahad AlSaleh🇬🇧King's College London
- Zoitsa Maniou🇬🇧King's College London
- Fiona J. Lewis🇬🇧King's College London
- Wendy Louise Hall🇬🇧King's College London
- T. A. B. Sanders🇬🇧King's College London
- Sandra D. O’Dell🇬🇧 · autor de correspondenciaKing's College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Delta-5 and delta-6 desaturases (D5D and D6D) are key enzymes in endogenous synthesis of long-chain PUFAs. In this sample of healthy subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1-FADS2 gene cluster were strongly associated with proportions of LC-PUFAs and desaturase activities estimated in plasma and erythrocytes. Minor allele carriage associated with decreased activities of D5D (FADS1) (5.84 × 10(-19) ≤ P ≤ 4.5 × 10(-18)) and D6D (FADS2) (6.05 × 10(-8) ≤ P ≤ 4.20 × 10(-7)) was accompanied by increased substrate and decreased product proportions (0.05 ≤ P ≤ 2.49 × 10(-16)). The significance of haplotype association with D5D activity (P = 2.19 × 10(-17)) was comparable to that of single SNPs, but haplotype association with D6D activity (P = 3.39 × 10(-28)) was much stronger. In a randomized controlled dietary intervention, increasing eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) intake significantly increased D5D (P = 4.0 × 10(-9)) and decreased D6D activity (P = 9.16 × 10(-6)) after doses of 0.45, 0.9, and 1.8 g/day for six months. Interaction of rs174537 genotype with treatment was a determinant of D5D activity estimated in plasma (P = 0.05). In conclusion, different sites at the FADS1-FADS2 locus appear to influence D5D and D6D activity, and rs174537 genotype interacts with dietary EPA+DHA to modulate D5D.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.