Effect of whole-body mild-cold exposure on arterial stiffness and central haemodynamics: a randomised, cross-over trial in healthy men and women
King SG, Ahuja KD, Wass J, Shing CM, Adams MJ, Davies JE, Sharman JE, Williams AD
European journal of applied physiology · 9 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- British Heart Foundation
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-11-17 · Eur J Appl Physiol · vol. 113 · número 5 · págs. 1257–1269
- Editorial
- Springer Science+Business Media
- Citado
- 9 citas · más que el 69% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control
- Palabras clave
- arterial stiffness, central hemodynamics, pulse wave velocity, augmentation index, ambient temperature, aortic pressure, brachial blood pressure, cardiovascular risk
- MeSH
- aorta, brachial artery, humans, cross-over studies, adult, female, male, hemodynamics, cold temperature, vascular stiffness
8 autores
- Sibella G K King🇦🇺University of Tasmania
- Kdk Ahuja🇦🇺University of Tasmania
- Jezreel Wass🇦🇺University of Tasmania
- Cecilia Mary Shing🇦🇺University of Tasmania
- Murray John Adams🇦🇺University of Tasmania
- Justin E. Davies🇬🇧Imperial College London
- James E. Sharman🇦🇺University of Tasmania
- Andrew Dafydd Williams🇦🇺 · autor de correspondenciaUniversity of Tasmania
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aortic pulse wave velocity (PWV) and augmentation index (AIx) are independent predictors of cardiovascular risk and mortality, but little is known about the effect of air temperature changes on these variables. Our study investigated the effect of exposure to whole-body mild-cold on measures of arterial stiffness (aortic and brachial PWV), and on central haemodynamics [including augmented pressure (AP), AIx], and aortic reservoir components [including reservoir and excess pressures (P ex)]. Sixteen healthy volunteers (10 men, age 43 ± 19 years; mean ± SD) were randomised to be studied under conditions of 12 °C (mild-cold) and 21 °C (control) on separate days. Supine resting measures were taken at baseline (ambient temperature) and after 10, 30, and 60 min exposure to each experimental condition in a climate chamber. There was no significant change in brachial blood pressure between mild-cold and control conditions. However, compared to control, AP [+2 mmHg, 95 % confidence interval (CI) 0.36-4.36; p = 0.01] and AIx (+6 %, 95 % CI 1.24-10.1; p = 0.02) increased, and time to maximum P ex (a component of reservoir function related to timing of peak aortic in-flow) decreased (-7 ms, 95 % CI -15.4 to 2.03; p = 0.01) compared to control. Yet there was no significant change in aortic PWV (+0.04 m/s, 95 % CI -0.47 to 0.55; p = 0.87) or brachial PWV (+0.36 m/s; -0.41 to 1.12; p = 0.35) between conditions. We conclude that mild-cold exposure increases central haemodynamic stress and alters timing of peak aortic in-flow without differentially affecting arterial stiffness.
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