Calcium and vitamin D supplementation and cognitive impairment in the women's health initiative
Rossom RC, Espeland MA, Manson JE, Dysken MW, Johnson KC, Lane DS, LeBlanc ES, Lederle FA, Masaki KH, Margolis KL
Journal of the American Geriatrics Society · 121 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- U.S. Public Health Service
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- WHI NIH HHS
- Gobierno
- PHS HHS
- Subvenciones
- National Institutes of Health (N01 WH044221); U.S. Public Health Service (44221); U.S. Public Health Service (32122); U.S. Public Health Service (24152); U.S. Public Health Service (42107-26); U.S. Public Health Service (42129-32); National Institutes of Health (N01 WH024152); U.S. Public Health Service (32118-32119); National Heart, Lung, and Blood Institute (N01 WH032118); U.S. Public Health Service (32100-2); National Heart, Lung, and Blood Institute (N01 WH042107); U.S. Public Health Service (32105-6); National Heart, Lung, and Blood Institute (N01 WH032105); U.S. Public Health Service (32108-9); U.S. Public Health Service (32111-13); U.S. Public Health Service (32115); National Institutes of Health (N01 WH032100); National Institutes of Health (N01 WH032108); National Institutes of Health (N01 WH022110); National Institutes of Health (N01 WH032118); National Institutes of Health (N01 WH042129); National Institutes of Health (N01 WH032115); National Institutes of Health (N01 WH032119); National Institutes of Health (N01 WH032111); National Institutes of Health (N01 WH042107); National Institutes of Health (N01 WH032122)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2012-11-23 · J Am Geriatr Soc · vol. 60 · número 12 · págs. 2197–2205
- Editorial
- Wiley
- Citado
- 170 citas · más que el 98% de estudios similares · 8.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dementia and Cognitive Impairment Research · Vitamin D Research Studies · Menopause: Health Impacts and Treatments
- Palabras clave
- calcium supplementation, vitamin D supplementation, cognitive impairment, dementia, mild cognitive impairment, older women, calcium carbonate, postmenopausal women
- MeSH
- humans, calcium carbonate, cholecalciferol, double-blind method, cognition, cognition disorders, dietary supplements, aged, aged, 80 and over, female
10 autores
- Rebecca C. Rossom🇺🇸University of Minnesota; HealthPartners
- Mark Andrew Espeland🇺🇸Wake Forest University Health Sciences; Wake Forest University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Maurice W. Dysken
- Karen Johnson🇺🇸Minneapolis VA Health Care System; Minneapolis VA Medical Center
- Dorothy S. Lane🇺🇸University of Tennessee Health Science Center
- Erin S. LeBlanc🇺🇸Stony Brook University
- Frank A. Lederle🇺🇸Oregon Health & Science University
- Kamal Masaki🇺🇸University of Hawaiʻi at Mānoa
- Karen L. Margolis🇺🇸University of Minnesota; HealthPartners
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To examine the effects of vitamin D and calcium on cognitive outcomes in elderly women.
Design
Post hoc analysis of a randomized double-blind placebo-controlled trial.
Setting
Forty Women's Health Initiative (WHI) clinical centers across the United States.
Participants
Four thousand one hundred forty-three women aged 65 and older without probable dementia at baseline who participated in the WHI Calcium and Vitamin D Trial and the WHI Memory Study.
Intervention
Two thousand thirty-four women were randomized to receive 1,000 mg of calcium carbonate combined with 400 IU of vitamin D(3) (treatment) and 2,109 to placebo.
Measurements
Primary: classifications of probable dementia or mild cognitive impairment (MCI) based on a four-phase protocol that included central adjudication. Secondary: global cognitive function and individual cognitive subtests.
Results
Mean age of participants was 71. During a mean follow-up of 7.8 years, 39 participants in the treatment group and 37 in the placebo group developed incident dementia (hazard ratio (HR) = 1.11, 95% confidence interval (CI) = 0.71-1.74, P = .64). Likewise, 98 treatment participants and 108 placebo participants developed incident MCI (HR = 0.95, 95% CI = 0.72-1.25, P = .72). There were no significant differences in incident dementia or MCI or in global or domain-specific cognitive function between groups.
Conclusion
There was no association between treatment assignment and incident cognitive impairment. Further studies are needed to investigate the effects of vitamin D and calcium separately, on men, in other age and ethnic groups, and with other doses.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.