Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies
Wu QJ, Yang Y, Vogtmann E, Wang J, Han LH, Li HL, Xiang YB
Annals of oncology : official journal of the European Society for Medical Oncology · 160 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Fogarty International Center
- Gobierno
- Fogarty International Clinical Research Scholars
- Gobierno
- R24 Training Grant
- Universidad u hospital
- at Birmingham
- Gobierno
- State Key Project Specialized for Infectious Diseases of China
- Universidad u hospital
- Fellows Support Center at the Vanderbilt Institute for Global Health
- Universidad u hospital
- Cancer Prevention and Control Training Program at the University of Alabama
- Gobierno
- NIH
- Subvenciones
- National Institutes of Health (5R25 CA047888)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2012-12-05 · Ann Oncol · vol. 24 · número 4 · págs. 1079–1087
- Editorial
- Elsevier BV
- Citado
- 216 citas · más que el 93% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 71 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Colorectal Cancer Screening and Detection · Cancer Risks and Factors
- Palabras clave
- cruciferous vegetables, colorectal cancer, colon cancer, cabbage, broccoli, dietary intake, cancer risk, inverse association, cancer prevention
- MeSH
- humans, brassicaceae, brassica, vegetables, colorectal neoplasms, risk factors, case-control studies, prospective studies
7 autores
- Qi‐Jun Wu🇨🇳Shanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Ya Ping Yang🇨🇳Shanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Emily Vogtmann🇺🇸University of Alabama at Birmingham
- J. Wang🇨🇳Shanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute
- Lihua Han🇨🇳Shanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute
- H.L. Li🇨🇳Shanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Yong‐Bing Xiang🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological studies have reported inconsistent associations between cruciferous vegetable (CV) intake and colorectal cancer (CRC) risk. To our knowledge, a comprehensive and quantitative assessment of the association between CV intake and CRC has not been reported.
Methods
Relevant articles were identified by searching MEDLINE. We pooled the relative risks (RR) from individual studies using a random-effect model and carried out heterogeneity and publication bias analyses.
Results
Twenty-four case-control and 11 prospective studies were included in our analysis. When all studies were pooled, we yielded a significantly inverse association between CV (RR: 0.82; 95% confidence interval 0.75-0.90) intake and CRC risk. Specific analysis for cabbage and broccoli yielded similar result. When separately analyzed, case-control studies of CV intake yield similar results, and the results from the prospective studies showed borderline statistical significance. Moreover, significant inverse associations were also observed in colon cancer and its distal subsite both among prospective and case-control studies.
Conclusions
Findings from this meta-analysis provide evidence that high intake of CV was inversely associated with the risk of CRC and colon cancer in humans. Further analysis on other specific CV, food preparation methods, stratified results by anatomic cancer site, and subsite of colon cancer should be extended in future study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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