Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies
Jolliffe DA, Griffiths CJ, Martineau AR
The Journal of steroid biochemistry and molecular biology · 172 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institute for Health Research (NIHR)
- Gobierno
- Medical Research Council
- Subvenciones
- National Institute for Health and Care Research (RP-PG-0407-10398)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2012-12-06 · J Steroid Biochem Mol Biol · vol. 136 · págs. 321–329
- Editorial
- Elsevier BV
- Citado
- 246 citas · más que el 84% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Respiratory viral infections research · Nutrition and Health Studies
- Palabras clave
- vitamin D, vitamin D deficiency, acute respiratory infections, vitamin D supplementation, upper respiratory tract infection, lower respiratory tract infection, 25-hydroxyvitamin D, infection control
- MeSH
- humans, respiratory tract infections, vitamin d deficiency, disease susceptibility, vitamin d, risk factors, epidemiologic studies, dietary supplements, clinical trials as topic
3 autores
- David A. Jolliffe🇬🇧 · autor de correspondenciaQueen Mary University of London
- Chris Griffiths🇬🇧Queen Mary University of London
- Adrian R. Martineau🇬🇧 · autor de correspondenciaQueen Mary University of London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D metabolites enhance immunity to a wide range of respiratory pathogens in vitro. Numerous observational studies have investigated whether vitamin D deficiency is a risk factor for acute respiratory infection, and a number of clinical trials of vitamin D supplementation for the prevention of acute respiratory infection have recently been conducted. Syntheses of this literature are lacking. We therefore conducted a systematic review of clinical studies investigating the association between vitamin D deficiency and susceptibility to acute respiratory infection in humans. A total of 39 studies (4 cross-sectional studies, 8 case-control studies, 13 cohort studies and 14 clinical trials) satisfying review eligibility criteria were identified. Observational studies predominantly reported statistically significant associations between low vitamin D status and increased risk of both upper and lower respiratory tract infections. Results from randomised controlled trials were conflicting however, reflecting heterogeneity in dosing regimens and baseline vitamin D status in study populations. Further trials of vitamin D supplementation for the prevention of acute respiratory infection should be conducted in populations with a high prevalence of vitamin D deficiency at baseline, using doses sufficient to induce sustained elevation of serum 25-hydroxyvitamin D concentrations, and powered to detect clinically important sub-group effects. This article is part of a Special Issue entitled 'Vitamin D Workshop'.
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