Nonlinear association between magnesium intake and the risk of colorectal cancer
Qu X, Jin F, Hao Y, Zhu Z, Li H, Tang T, Dai K
European journal of gastroenterology & hepatology · 22 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-12-07 · Eur J Gastroenterol Hepatol · vol. 25 · número 3 · págs. 309–318
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 33 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Magnesium in Health and Disease · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, colorectal cancer, colon cancer, rectal cancer, nonlinear dose-response relationship, cancer risk reduction, sex differences, confounding
- MeSH
- humans, colorectal neoplasms, magnesium, diet, odds ratio, risk assessment, risk factors, dose-response relationship, drug, nonlinear dynamics, time factors, adult, aged, middle aged, female, male
7 autores
- Xinhua Qu🇨🇳Shanghai Jiao Tong University; Shanghai Ninth People's Hospital
- Fangchun Jin🇨🇳Shanghai Jiao Tong University; Shanghai Ninth People's Hospital
- Yongqiang Hao🇨🇳Shanghai Jiao Tong University; Shanghai Ninth People's Hospital
- Zhenan Zhu🇨🇳Shanghai Jiao Tong University; Shanghai Ninth People's Hospital
- Huiwu Li🇨🇳Shanghai Jiao Tong University; Shanghai Ninth People's Hospital
- Tingting Tang🇨🇳Shanghai Jiao Tong University; Shanghai Ninth People's Hospital
- Kerong Dai🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; Shanghai Ninth People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
The association between dietary magnesium intake and the risk of colorectal cancer has been examined by many prospective studies, but remains controversial because of inconsistent results. We aimed to carry out a meta-analysis to investigate this.
Materials and methods
We assessed this association with categorical and dose-response meta-analysis of data from prospective cohort studies. Relevant studies were identified by searching MEDLINE, EMBASE, and OVID for studies published before 9 June 2012, with no restrictions. Relative risks (RRs) and 95% confidence intervals (CIs) for the highest versus lowest and dose-response association were estimated using random-effects models. Heterogeneity and publication bias was investigated, and subgroup, sensitivity, and meta-regression analyses were carried out.
Results
The analysis included 333 510 participants with 7435 colorectal cancers from seven prospective cohort studies. The summary RR for the highest versus the lowest intake of dietary magnesium was 0.81 (95% CI: 0.70-0.92) for colorectal cancer, 0.76 (95% CI: 0.64-0.88) for colon cancer, and 0.82 (95% CI: 0.58-1.06) for rectal cancer. For men and women, the pooled RR was 0.76 (95% CI: 0.51-1.01) and 0.81 (95% CI: 0.68-0.94), respectively. Significant inverse associations of colorectal cancer and dietary magnesium emerged in nonlinear models (p nonlinearity=0.03). The greatest risk reduction was observed when dietary magnesium intake increased from very low levels.
Conclusion
Dietary magnesium intake has a statistically significant nonlinear inverse association with the risk of colorectal cancer. The greatest reduction for magnesium intake is 200-270 mg/day. Whether the association is causal or because of confounding warrants further investigation.
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