Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy--a randomized controlled trial
Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Nigudgi S
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 76 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Board of Research in Nuclear Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-12-07 · Support Care Cancer · vol. 21 · número 5 · págs. 1421–1428
- Editorial
- Springer Science+Business Media
- Citado
- 109 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, head and neck cancer, chemoradiotherapy, quality of life, patient-reported outcomes, cisplatin, radiation-induced mucositis, oral pain, opioid analgesic use, He-Ne laser
- MeSH
- humans, head and neck neoplasms, stomatitis, analgesics, opioid, treatment outcome, parenteral nutrition, total, severity of illness index, analysis of variance, linear models, double-blind method, quality of life, adult, aged, middle aged, female, male, chemoradiotherapy, surveys and questionnaires, low-level light therapy
5 autores
- Ajay Prashad Gautam🇮🇳 · autor de correspondenciaManipal Academy of Higher Education; Kasturba Medical College Hospital; Kasturba Medical College, Manipal
- Donald Fernandes🇮🇳Manipal Academy of Higher Education; Kasturba Medical College Hospital; Kasturba Medical College, Manipal
- Mamidipudi Srinivasa Vidyasagar🇮🇳Father Muller Medical College Hospital
- Arun Gundmi Maiya🇮🇳Manipal Academy of Higher Education; Kasturba Medical College Hospital; Kasturba Medical College, Manipal
- Shantling Nigudgi🇮🇳Apollo Hospitals
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Chemoradiotherapy (CRT)-induced oral mucositis (OM) adversely affects a patient's oral functions and quality of life (QOL). Low-level laser therapy (LLLT) showed some preventive and curative effects against clinically reported objective measures of OM in few trials including our recently published study. There is dearth of evidence regarding the effects of LLLT on patient's subjective experience of OM and QOL. Hence, we did this study to evaluate the effects of LLLT on a patient's reported measures of OM and QOL in head and neck cancer (HNC) patients receiving CRT.
Methods
This triple blinded study randomized 220 HNC patients scheduled for CRT (three weekly Cisplatin + RT = 66 Gray (2 Gy/session), five fractions/week for 6.5 weeks, total 33 fractions) into laser (110) and placebo (110) groups. The laser group received LLLT (Technomed Electronics Advanced Laser Therapy 1000, He-Ne, λ = 632.8 nm, power density = 24 mW/cm(2), dosage = 3.0 J at each point, total dose/session = 36-40 J, spot size 1 cm(2), irradiation time/point 125 s) before each radiation session, while the placebo group did not receive laser therapy. Methodology was similar to our recently published study (Gautam et al. Radiother Oncol 104:349-354, 2012). In this part of our study, a blinded assessor collected subjective outcomes of the patient's reported measures of OM using Oral Mucositis Weekly Questionnaire-Head and Neck (OMWQ-HN) and QOL using Functional Assessment of Cancer Treatment-Head and Neck (FACT-HN) Questionnaire. Data were analyzed using repeated measure ANOVA through general linear model. Statistical significance was kept at p < 0.05.
Results
Results analysis revealed that OMWQ-HN (F = 12.199, df = 6,1314, p < 0.001) and FACT-HN (p < 0.05) scores were significantly lower in LLLT than placebo group patients. Also, a significant reduction (p < 0.001) in incidence of severe OM, need for opioid analgesics, and total parenteral nutrition was observed.
Conclusions
LLLT was effective in improving the patient's subjective experience of OM and QOL in HNC patients receiving CRT.
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