25-hydroxyvitamin D and symptomatic ischemic stroke: an original study and meta-analysis
Brøndum-Jacobsen P, Nordestgaard BG, Schnohr P, Benn M
Annals of neurology · 157 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Hjerteforeningen
Según 1 financiador declarado.
Publicación
- Publicado
- 2012-08-25 · Ann Neurol · vol. 73 · número 1 · págs. 38–47
- Editorial
- Wiley
- Citado
- 225 citas · más que el 99% de estudios similares · 13.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Vitamin K Research Studies · Acute Ischemic Stroke Management
- Palabras clave
- 25-hydroxyvitamin D, vitamin D deficiency, ischemic stroke, hemorrhagic stroke, plasma vitamin D levels, stroke risk, vitamin D status, Copenhagen City Heart Study
- MeSH
- humans, brain ischemia, vitamin d, population surveillance, risk factors, follow-up studies, prospective studies, aged, middle aged, denmark, female, male, stroke, biomarkers
4 autores
- Peter Brøndum-Jacobsen🇩🇰University of Copenhagen; Herlev Hospital; Copenhagen University Hospital
- Børge Grønne Nordestgaard🇩🇰University of Copenhagen; Herlev Hospital; Bispebjerg Hospital; Copenhagen University Hospital
- Peter Schnohr🇩🇰Bispebjerg Hospital; Copenhagen University Hospital
- Marianne Benn🇩🇰 · autor de correspondenciaUniversity of Copenhagen; Herlev Hospital; Copenhagen University Hospital; Gentofte Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We tested the hypothesis that low plasma concentrations of 25-hydroxyvitamin D are associated with increased risk of symptomatic ischemic stroke in the general population.
Methods
We measured plasma 25-hydroxyvitamin D in 10,170 individuals from the general population, the Copenhagen City Heart Study. During 21 years of follow-up, 1,256 and 164 persons developed ischemic and hemorrhagic stroke, respectively. In a meta-analysis of ischemic stroke, we included 10 studies, 58,384 participants, and 2,644 events.
Results
Stepwise decreasing plasma 25-hydroxyvitamin D concentrations were associated with stepwise increasing risk of ischemic stroke both as a function of seasonally adjusted percentile categories and as a function of clinical categories of 25-hydroxyvitamin D (p for trend ≤ 2 × 10(-3)). In a Cox regression model comparing individuals with plasma 25-hydroxyvitamin D concentrations between the 1st and 4th percentiles to individuals with 25-hydroxyvitamin D concentrations between the 50th and 100th percentiles, multivariate adjusted hazard ratio of ischemic stroke was 1.82 (95% confidence interval, 1.41-2.34). Comparing individuals with clinical categories of severe vitamin D deficiency (<25.0 nmol/l [<10.0 ng/ml]) to individuals with optimal vitamin D status (≥75.0 nmol/l [≥30.0 ng/ml]), the multivariate adjusted hazard ratio of ischemic stroke was 1.36 (1.09-1.70). 25-Hydroxyvitamin D concentrations were not associated with risk of hemorrhagic stroke. In a meta-analysis comparing lowest versus highest quartile of 25-hydroxyvitamin D concentrations, the multivariate adjusted odds ratio of ischemic stroke was 1.54 (1.43-1.65) with a corresponding hazard ratio of 1.46 (1.35-1.58) in prospective general population studies.
Interpretation
In this large population-based prospective study, we observed stepwise increasing risk of symptomatic ischemic stroke with decreasing plasma 25-hydroxyvitamin D concentrations. This finding was substantiated in a meta-analysis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.