Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis
Afzal S, Bojesen SE, Nordestgaard BG
Clinical chemistry · 207 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Hjerteforeningen
- Universidad u hospital
- Gentofte Hospital
- Universidad u hospital
- Herlev Hospital
Según 3 financiadores declarados.
Publicación
- Publicado
- 2012-12-12 · Clin Chem · vol. 59 · número 2 · págs. 381–391
- Editorial
- American Association for Clinical Chemistry
- Citado
- 299 citas · más que el 99% de estudios similares · 13.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- 25-hydroxyvitamin D, vitamin D deficiency, type 2 diabetes, diabetes risk, insulin resistance, insulin secretion, seasonal variation, general population
- MeSH
- humans, diabetes mellitus, type 2, vitamin d deficiency, vitamin d, incidence, prospective studies, aged, middle aged, denmark, female, male
3 autores
- Shoaib Afzal🇩🇰Herlev Hospital; Copenhagen University Hospital
- Stig E. Bojesen🇩🇰University of Copenhagen; Herlev Hospital; Bispebjerg Hospital; Copenhagen University Hospital
- Børge Grønne Nordestgaard🇩🇰 · autor de correspondenciaUniversity of Copenhagen; Herlev Hospital; Bispebjerg Hospital; Copenhagen University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D deficiency has been implicated in decreased insulin secretion and increased insulin resistance, hallmarks of type 2 diabetes mellitus. We tested the hypothesis that low plasma 25-hydroxyvitamin D [25(OH)D] is associated with increased risk of type 2 diabetes in the general population.
Methods
We measured 25(OH)D in 9841 participants from the general population, of whom 810 developed type 2 diabetes during 29 years of follow-up. Analyses were adjusted for sex, age, smoking status, body mass index, income, physical activity, HDL cholesterol, and calendar month of blood draw.
Results
Lower 25(OH)D concentrations, by clinical categories or seasonally adjusted quartiles, were associated with higher cumulative incidence of type 2 diabetes (trend, P = 2×10(-7) and P = 4×10(-10)). Multivariable adjusted hazard ratios of type 2 diabetes were 1.22 (95% CI 0.85-1.74) for 25(OH)D <5 vs ≥20 μg/L and 1.35 (1.09-1.66) for lowest vs highest quartile. Also, the multivariable adjusted hazard ratio of type 2 diabetes for a 50% lower concentration of 25(OH)D was 1.12 (1.03-1.21); the corresponding hazard ratio for those ≤58 years old was 1.26 (1.15-1.41). Finally, in a metaanalysis of 16 studies, the odds ratio for type 2 diabetes was 1.50 (1.33-1.70) for the bottom vs top quartile of 25(OH)D.
Conclusions
We observed an association of low plasma 25(OH)D with increased risk of type 2 diabetes. This finding was substantiated in a metaanalysis.
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