Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model
Kim HV, Kim HY, Ehrlich HY, Choi SY, Kim DJ, Kim Y
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · 126 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-12-19 · Amyloid · vol. 20 · número 1 · págs. 7–12
- Editorial
- Taylor & Francis
- Citado
- 153 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Cholinesterase and Neurodegenerative Diseases · Tryptophan and brain disorders
- Palabras clave
- Sulforaphane, Chemistry, Neuroprotection, Antioxidant, Oxidative stress, Reactive oxygen species, Pharmacology, Dimethyl sulfoxide, Glutathione, Biochemistry, Medicine, Enzyme
- MeSH
- hippocampus, neurons, cell line, animals, mice, inbred icr, humans, mice, alzheimer disease, disease models, animal, reactive oxygen species, thiocyanates, isothiocyanates, sulfoxides, neuroprotective agents, antioxidants, cognition, avoidance learning, maze learning, oxidative stress, male, amyloid beta-peptides
6 autores
- Hyunjin Vincent Kim🇰🇷Korea Institute of Brain Science; Korea Institute of Science and Technology
- Hye Yun Kim🇰🇷Korea Institute of Brain Science; Korea Institute of Science and Technology
- Hanna Y. Ehrlich🇺🇸🇰🇷Tufts University; Korea Institute of Brain Science; Korea Institute of Science and Technology
- Seon Young Choi🇰🇷Korea Institute of Brain Science; Korea Institute of Science and Technology
- Dong Jin Kim🇰🇷Korea Institute of Brain Science; Korea Institute of Science and Technology
- Young Soo Kim🇰🇷 · autor de correspondenciaKorea Institute of Brain Science; Korea Institute of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Pathophysiological evidences of AD have indicated that aggregation of Aβ is one of the principal causes of neuronal dysfunction, largely by way of inducing oxidative stresses such as free radical formation. We hypothesized that the known antioxidative attribute of SFN could be harnessed in Alzheimer's treatment. SFN is an indirect, potent antioxidant derived from broccoli that has previously been found to stimulate the Nrf2-ARE pathway and facilitate several other cytoprotective mechanisms. In this study, administration of SFN ameliorated cognitive function of Aβ-induced AD acute mouse models in Y-maze and passive avoidance behavior tests. Interestingly, we found that the therapeutic effect of SFN did not involve inhibition of Aβ aggregation. While the exact mechanism of interaction of SFN in AD has not yet been ascertained, our results suggest that SFN can aid in cognitive impairment and may protect the brain from amyloidogenic damages.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.