Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis'
Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F
BMC infectious diseases · 152 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-01-19 · BMC Infect Dis · vol. 13 · número 1 · pág. 22
- Editorial
- BioMed Central
- Citado
- 241 citas · más que el 100% de estudios similares · 18.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Tuberculosis Research and Epidemiology · Vitamin D Research Studies · Infectious Diseases and Tuberculosis
- Palabras clave
- vitamin D supplementation, pulmonary tuberculosis, vitamin D3, interferon-gamma, Mycobacterium tuberculosis, host immune response, 25-hydroxyvitamin D deficiency, weight gain, ESAT-6, whole blood stimulation
- MeSH
- humans, mycobacterium tuberculosis, tuberculosis, pulmonary, vitamin d, bacterial proteins, antigens, bacterial, treatment outcome, dietary supplements, adolescent, adult, female, male, interferon-gamma, young adult
6 autores
- Nawal Salahuddin🇸🇦 · autor de correspondenciaKing Faisal Specialist Hospital & Research Centre
- Farheen Ali🇵🇰Aga Khan University
- Zahra Hasan🇵🇰Aga Khan University
- Nisar Ahmed Rao
- Masooma Aqeel🇵🇰Aga Khan University
- Faisal Mahmood🇵🇰Aga Khan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D enhances host protective immune responses to Mycobacterium tuberculosis by suppressing Interferon-gamma (IFN-g) and reducing disease associated inflammation in the host. The objectives of this study were to determine whether vitamin D supplementation to patients with tuberculosis (TB) could influence recovery.
Methods
Two hundred and fifty nine patients with pulmonary TB were randomized to receive either 600,000 IU of Intramuscular vitamin D3 or placebo for 2 doses. Assessments were performed at 4, 8 and 12 weeks. Early secreted and T cell activated 6 kDa (ESAT6) and Mycobacterium tuberculosis sonicate (MTBs) antigen induced whole blood stimulated IFN-g responses were measured at 0 and 12 weeks. Statistical comparisons between outcome variables at 0 and 12 weeks were performed using Student's t-test and Chi2 tests.
Results
After 12 weeks, the vitamin D supplemented arm demonstrated significantly greater mean weight gain (kg)+3.75, (3.16-4.34) versus+2.61 (95% CI 1.99-3.23) p 0.009 and lesser residual disease by chest radiograph; number of zones involved 1.35 v/s 1.82 p 0.004 (95% CI 0.15, 0.79) and 50% or greater reduction in cavity size 106 (89.8%) v/s 111 (94.8%), p 0.035. Vitamin D supplementation led to significant increase in MTBs-induced IFN-g secretion in patients with baseline 'Deficient' 25-hydroxyvitamin D serum levels (p 0.021).
Conclusions
Supplementation with high doses of vitamin D accelerated clinical, radiographic improvement in all TB patients and increased host immune activation in patients with baseline 'Deficient' serum vitamin D levels. These results suggest a therapeutic role for vitamin D in the treatment of TB.
Trial registration
ClinicalTrials.gov; No. NCT01130311; URL: clinicaltrials.gov.
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