Serum 25-hydroxy vitamin D levels in relation to body mass index: a systematic review and meta-analysis
Saneei P, Salehi-Abargouei A, Esmaillzadeh A
Obesity reviews : an official journal of the International Association for the Study of Obesity · 150 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-01-18 · Obes Rev · vol. 14 · número 5 · págs. 393–404
- Editorial
- Wiley
- Citado
- 217 citas · más que el 93% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 85 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Bone health and osteoporosis research
- Palabras clave
- vitamin D, 25-hydroxyvitamin D, body mass index, obesity, vitamin D deficiency, vitamin D status, healthy adults, sex differences, regional variation, latitude, developing countries, developed countries, study heterogeneity, meta-regression, correlation coefficient, cross-sectional study, vitamin D supplementation
- MeSH
- humans, vitamin d, body mass index, cross-sectional studies, sex factors, cross-cultural comparison, developing countries, female, male
3 autores
- Parvane Saneei🇮🇷Isfahan University of Medical Sciences
- Amin Salehi‐Abargouei🇮🇷Isfahan University of Medical Sciences
- Ahmad Esmaillzadeh🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although several cross-sectional studies have investigated serum vitamin D levels in relation to body mass index (BMI), findings are inconsistent.
Objective
This systematic review and meta-analysis of published cross-sectional data was conducted to summarize the evidence on the link between serum vitamin D levels and BMI in adults.
Methods
PubMed, ISI Web of Science, Scopus and Google scholar database were searched to May 2012 for all relevant published papers. We found 34 articles that reported the correlation coefficients between serum 25-hydroxy vitamin D (25(OH)D) levels and BMI in apparently healthy adults (>18 years). The primary analysis was done on these 34 papers that reported 37 correlation coefficients. To find the source of between-study heterogeneity, our secondary analysis was confined to eight studies that had used random sampling method and reported the correlations for the whole population.
Results
Our meta-analysis on 34 relevant papers revealed an overall significant inverse, but weak, association between serum 25(OH)D levels and BMI (Fisher's Z = -0.15, 95% CI: -0.19, -0.11) with a significant heterogeneity between studies. In the subgroup analysis based on gender and study location (East vs. West), the inverse associations were significant in both genders (male: Fisher's Z = -0.11, 95% CI: -0.14, -0.08 and female: -0.14, 95% CI: -0.21, -0.08) and both study locations (East: -0.09, 95% CI: -0.14, -0.04 and West: -0.23, 95% CI: -0.31, -0.17). In the subgroup analysis based on developmental status of countries, the weak inverse association remained significant in developed countries (-0.17, 95% CI: -0.21, -0.14), but not in developing nations (-0.10, 95% CI: -0.20, 0.01). Using meta-regression, we found that latitude (P = 0.91) or longitude (P = 0.2) of cities did not significantly contribute to the computed effect sizes. When we restricted our analysis to eight selected studies that used random sampling method, we reached the same findings. In this analysis, gender and developmental status of countries explained the between-study heterogeneity.
Conclusion
There is a significant inverse weak correlation between serum 25(OH)D levels and BMI in adult population, except for women living in developing countries. Further research particularly in developing countries and populations living near the equator is needed.
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