Low-level laser treatment with near-infrared light increases venous nitric oxide levels acutely: a single-blind, randomized clinical trial of efficacy
Mitchell UH, Mack GL
American journal of physical medicine & rehabilitation · 27 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-09-06 · Am J Phys Med Rehabil · vol. 92 · número 2 · págs. 151–156
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 58 citas · más que el 88% de estudios similares · 2.7× el promedio de su campo
- Referencias
- 18 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Biofield Effects and Biophysics · Photodynamic Therapy Research Studies
- Palabras clave
- low-level laser therapy, near-infrared light, nitric oxide, nitrite, nitrate, venous blood, peripheral blood flow
- MeSH
- forearm, humans, nitrates, nitrites, nitric oxide, analysis of variance, single-blind method, adult, female, male, young adult, low-level light therapy
2 autores
- Ulrike H. Mitchell🇺🇸 · autor de correspondenciaBrigham Young University
- Gary L. Mack🇺🇸Brigham Young University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The use of near-infrared light in the form of low-level laser therapy (LLLT) has become more popular in the treatment of a variety of conditions where increased peripheral blood flow is desired. The hypothesis behind its working mechanism is its purported ability to generate nitric oxide (NO) in the treated area. We tested the hypothesis that the efficacy of near-infrared light lies in its ability to generate NO at the treatment site.
Design
We conducted a single-blind, placebo-controlled, randomized clinical trial to measure NO, by its metabolites nitrite and nitrate, in venous blood draining from tissue receiving LLLT. Fifteen healthy subjects received LLLT to the forearm, and blood samples were taken immediately before treatment; at 1, 5, 15, and 30 mins; as well as 15 mins after the treatment to check for NO content.
Results
We found a significant treatment effect (F = 15.75, P = 0.003). A post hoc test showed that minutes 1, 5, and 15 were different compared with the baseline measures (P's < 0.05). The area under the treatment curve was significantly larger than the area under the sham treatment curve (t = 2.26, P = 0.037). A limitation of this study was that the data were collected from healthy subjects.
Conclusions
LLLT increased NO levels in venous blood draining from the treatment site in healthy subjects. The peak increase in NO occurred 5 mins into the treatment, after which it slowly waned. Further research is necessary to assess NO increases with LLLT in patients with pathologies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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