Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies
Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimäki T, Lemaitre RN, Manichaikul A, North KE, Ntalla I, Sonestedt E, Tanaka T, van Rooij FJ, Bandinelli S, Djoussé L, Grigoriou E, Johansson I, Lohman KK, Pankow JS, Raitakari OT, Riserus U, Yannakoulia M, Zillikens MC, Hassanali N, Liu Y, Mozaffarian D, Papoutsakis C, Syvänen AC, Uitterlinden AG, Viikari J, Groves CJ, Hofman A, Lind L, McCarthy MI, Mikkilä V, Mukamal K, Franco OH, Borecki IB, Cupples LA, Dedoussis GV, Ferrucci L, Hu FB, Ingelsson E, Kähönen M, Kao WH, Kritchevsky SB, Orho-Melander M, Prokopenko I, Rotter JI, Siscovick DS, Witteman JC, Franks PW, Meigs JB, McKeown NM, Nettleton JA
The Journal of nutrition · 42 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK080140); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK078616); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK063491); National Institutes of Health (UL1TR000124); National Heart, Lung, and Blood Institute (R01-HL087700); National Heart, Lung, and Blood Institute (R01 HL105756); Wellcome Trust (090532)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2013-01-24 · J Nutr · vol. 143 · número 3 · págs. 345–353
- Editorial
- Elsevier BV
- Citado
- 56 citas · más que el 75% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Nutrition, Genetics, and Disease · Nutritional Studies and Diet
- Palabras clave
- dietary magnesium, fasting blood glucose, fasting insulin, glycemic traits, genetic susceptibility, single nucleotide polymorphisms, gene-diet interaction, TRPM6, SLC30A8, CNNM2, magnesium metabolism, CHARGE consortium
- MeSH
- humans, magnesium, trace elements, insulin, blood glucose, polymorphism, single nucleotide, female, male, trpm cation channels, genetic loci
59 autores
- Adela Hruby🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Julius Suh Ngwa🇺🇸Boston University
- Frida Renström🇺🇸🇸🇪Harvard University; Lund University; Umeå University
- Mary K. Wojczynski🇺🇸Washington University in St. Louis
- Andrea Ganna🇸🇪Karolinska Institutet
- Göran Hallmans🇸🇪Umeå University
- Denise K. Houston🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Paul F. Jacques🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Stavroula Kanoni🇬🇷🇬🇧National and Kapodistrian University of Athens; Wellcome Sanger Institute; Harokopio University of Athens
- Terho J. Lehtimäki🇫🇮Tampere University; Tampere University Hospital; Fimlab (Finland); University of Tampere
- Rozenn N. Lemaître🇺🇸University of Washington
- Ani W Manichaikul🇺🇸University of Virginia
- Kari E. North🇺🇸University of North Carolina at Chapel Hill
- Ιωάννα Ντάλλα🇺🇸National Institutes of Health; National Institute on Aging
- Emily Sonestedt🇸🇪Lund University
- Toshiko Tanaka🇺🇸National Institutes of Health; National Institute on Aging
- Frank J.A. van Rooij🇳🇱Erasmus MC; Netherlands Consortium for Healthy Ageing; Erasmus University Rotterdam
- Stefania Bandinelli🇮🇹Azienda Sanitaria di Firenze
- Luc Djoussé🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
- Efi Grigoriou🇬🇷National and Kapodistrian University of Athens; Harokopio University of Athens
- Ingegerd Johansson🇸🇪Umeå University
- Kurt K. Lohman🇺🇸Wake Forest University
- James S. Pankow🇺🇸University of Minnesota
- Olli Tuomas Raitakari🇫🇮University of Turku; Turku University Hospital
- Ulf Risérus🇸🇪Uppsala University
- Mary Yannakoulia🇬🇷National and Kapodistrian University of Athens; Harokopio University of Athens
- M. Carola Zillikens🇳🇱Erasmus University Rotterdam
- Neelam Hassanali🇬🇧University of Oxford; Oxford Centre for Diabetes, Endocrinology and Metabolism
- Yongmei Liu🇺🇸Wake Forest University
- Dariush Mozaffarian🇺🇸Harvard University
- Constantina Papoutsakis🇬🇷National and Kapodistrian University of Athens; Harokopio University of Athens
- Ann‐Christine Syvänen
- André Gerardus Uitterlinden🇳🇱Erasmus University Rotterdam
- Jorma S.A. Viikari🇺🇸VA Boston Healthcare System
- Christopher J. Groves🇬🇧University of Oxford; Oxford Centre for Diabetes, Endocrinology and Metabolism
- Albert Hofman D🇳🇱Erasmus MC; Netherlands Consortium for Healthy Ageing; Erasmus University Rotterdam
- Lars Lind🇸🇪🇺🇸Uppsala University; VA Boston Healthcare System
- Mark I. McCarthy🇬🇧University of Oxford; Oxford Centre for Diabetes, Endocrinology and Metabolism
- Vera Mikkilä🇫🇮🇺🇸University of Helsinki; VA Boston Healthcare System
- Kenneth Jay Mukamal🇺🇸Beth Israel Deaconess Medical Center; VA Boston Healthcare System
- Oscar H. Franco🇳🇱Erasmus MC; Netherlands Consortium for Healthy Ageing; Erasmus University Rotterdam
- Ingrid B. Borecki🇺🇸Washington University in St. Louis
- L. Adrienne Cupples🇺🇸Boston University
- George V. Dedoussis🇬🇷National and Kapodistrian University of Athens; Harokopio University of Athens
- Luigi Ferrucci🇺🇸National Institutes of Health; National Institute on Aging
- Frank B. Hu🇺🇸Harvard University
- Erik Ingelsson🇸🇪Karolinska Institutet
- Mika A. P. Kähönen🇫🇮Tampere University
- W.H. Linda Kao🇺🇸Johns Hopkins University; VA Boston Healthcare System
- Stephen B. Kritchevsky🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Marju Orho‐Melander🇸🇪Lund University
- Inga Prokopenko🇬🇧Centre for Human Genetics; University of Oxford; Oxford Centre for Diabetes, Endocrinology and Metabolism
- Jerome I. Rotter🇺🇸Cedars-Sinai Medical Center; VA Boston Healthcare System
- David S. Siscovick🇺🇸University of Washington
- Jacqueline C.M. Witteman🇳🇱Erasmus MC; Netherlands Consortium for Healthy Ageing; Erasmus University Rotterdam
- Paul W. Franks🇺🇸🇸🇪Harvard University; Lund University; Umeå University
- James B. Meigs🇺🇸Harvard University; VA Boston Healthcare System
- Nicola Mary McKeown🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Jennifer A. Nettleton🇺🇸The University of Texas Health Science Center at Houston
Resumen
El texto original del estudio, en el idioma en que se publicó.
Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI: -0.024, -0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.