Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults
Kontogianni MD, Vlassopoulos A, Gatzieva A, Farmaki AE, Katsiougiannis S, Panagiotakos DB, Kalogeropoulos N, Skopouli FN
Metabolism: clinical and experimental · 59 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Harokopio University
Según 1 financiador declarado.
Publicación
- Publicado
- 2013-01-22 · Metabolism · vol. 62 · número 5 · págs. 686–693
- Editorial
- Elsevier BV
- Citado
- 75 citas · más que el 95% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Nutritional Studies and Diet
- Palabras clave
- linseed oil, olive oil, dietary fat, alpha-linolenic acid, omega-3 fatty acids, inflammatory markers, adiponectin, TNF-α, high-sensitivity C-reactive protein, lipid profile, LDL cholesterol, erythrocyte fatty acids, eicosapentaenoic acid, healthy young adults
- MeSH
- humans, linseed oil, plant oils, inflammation mediators, cross-over studies, age factors, adolescent, adult, health, female, male, lipid metabolism, metabolome, young adult, ideal body weight, biomarkers, olive oil
8 autores
- Meropi D. Kontogianni🇬🇷Harokopio University of Athens
- Antonis Vlassopoulos🇬🇷Harokopio University of Athens
- Alexandra Gatzieva🇬🇷Harokopio University of Athens
- Aliki‐Eleni Farmaki🇬🇷Harokopio University of Athens
- Stergios Katsiougiannis🇬🇷Harokopio University of Athens
- Demosthenes B. Panagiotakos🇬🇷Harokopio University of Athens
- Nick Kalogeropoulos🇬🇷Harokopio University of Athens
- Fotini N. Skopouli🇬🇷 · autor de correspondenciaHarokopio University of Athens
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Olive oil (OO) is a rich source of monounsaturated fat and bioactive components that exert strong anti-oxidant and anti-inflammatory properties. Flaxseed oil (FO) is rich in α-linolenic n-3 fatty acid (ALA), which also exhibits anti-inflammatory effects. This randomized, cross-over study aimed at exploring whether diet's enrichment with FO could beneficially alter inflammatory markers and lipid profile, compared to OO, in a sample of normal weight, apparently healthy young adults.
Materials and methods
Participants were supplied with 15 mL/day of either FO or OO. Each intervention and the wash-out period lasted 6 weeks. Dietary, anthropometric and physical activity variables were recorded at the beginning and the end of each intervention. Serum biochemical and inflammatory markers were measured. Compliance to the intervention was evaluated by fatty acid analysis in erythrocytes. Repeated Measures ANOVA was used to assess the effect of the treatment.
Results
Thirty seven participants completed the study. No difference between the two interventions was observed in adiponectin, TNF-α, high sensitivity-CRP or glucose levels and lipid profile. At the end of the FO period, participants exhibited significant reductions in total (-5.0%) and LDL-cholesterol (-6.7%) levels (all P<0.01). During the FO and the OO period serum adiponectin changes were significantly correlated with changes in erythrocyte %ALA (rs=0.34, P=0.007) and in erythrocyte %EPA (r(s)=0.47, P=0.01), respectively.
Conclusions
Daily consumption of FO did not confer any benefit in inflammatory or biochemical markers in normal weight young adults, who traditionally use olive oil as the main edible oil.
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