Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions
Fulford J, Winyard PG, Vanhatalo A, Bailey SJ, Blackwell JR, Jones AM
Pflugers Archiv : European journal of physiology · 92 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-01-25 · Pflugers Arch · vol. 465 · número 4 · págs. 517–528
- Editorial
- Springer Science+Business Media
- Citado
- 118 citas · más que el 100% de estudios similares · 27.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Muscle metabolism and nutrition · Exercise and Physiological Responses
- Palabras clave
- nitrate supplementation, beetroot juice, nitric oxide bioavailability, maximal voluntary contraction, isometric contraction, energy cost of exercise, exercise performance
- MeSH
- muscle, skeletal, humans, nitrates, exercise, isometric contraction, dietary supplements, adult, male, muscle strength
6 autores
- Jonathan Fulford🇬🇧 · autor de correspondenciaUniversity of Exeter; NIHR Exeter Clinical Research Facility
- Paul Graham Winyard🇬🇧University of Exeter
- Anni Vanhatalo🇬🇧University of Exeter
- Stephen J. Bailey🇬🇧University of Exeter
- Jamie R. Blackwell🇬🇧University of Exeter
- ANDREW MARK JONES🇬🇧University of Exeter
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate supplementation, which enhances nitric oxide (NO) bioavailability, has previously been shown to contribute to improved exercise performance by reducing both oxygen cost and energy expenditure. In contrast, previous studies have indicated that NO can lower force production in vitro. To examine the role of dietary nitrates in regulating force generation under normal physiological conditions, we undertook an extended nitrate supplementation regime and determined force output and energy cost with a repeated isometric maximum voluntary contraction (MVC) protocol. In a double-blind, randomized, crossover design, eight participants received 0.5 l/day of nitrate-rich (BR) or nitrate-depleted (PL) beetroot juice for 15 days and completed an exercise protocol consisting of 50 MVCs at 2.5 h, 5 days and 15 days after the beginning of the supplementation period. No significant reduction in force output was determined for BR relative to PL for the peak contraction, the mean or the end force, and no significant time effect was found over the course of the supplementation period. There was a reduction in the mean PCr cost of exercise averaged over the BR supplementation trials, but this did not reach statistical significance for end exercise (BR 15.10 ± 4.14 mM, PL 17.10 ± 5.34 mM, P = 0.06) or the mean throughout the protocol (BR 15.96 ± 4.14 mM, PL 17.79 ± 4.51 mM, P = 0.06). However, a significant reduction in PCr cost per unit force output was found for BR at end exercise (P = 0.04). These results indicate that, under normal physiological conditions, increased NO bioavailability is not associated with a reduction of force-generating capability in human skeletal muscle and confirm that nitrate supplementation reduces the PCr cost of force production.
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