Whole grains, type 2 diabetes, coronary heart disease, and hypertension: links to the aleurone preferred over indigestible fiber
Lillioja S, Neal AL, Tapsell L, Jacobs DR
BioFactors (Oxford, England) · 43 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Sveriges Lantbruksuniversitet
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R56 HL053560); National Cancer Institute (CA 58420); National Institute of Diabetes and Digestive and Kidney Diseases (DK068738); National Cancer Institute (R01- CA058420); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK068738); Biotechnology and Biological Sciences Research Council (BBS/E/C/00005206)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2013-01-28 · Biofactors · vol. 39 · número 3 · págs. 242–258
- Editorial
- Wiley
- Citado
- 82 citas · más que el 94% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 194 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Magnesium in Health and Disease
- Palabras clave
- Whole grains, Bran, Refined grains, Medicine, Aleurone, Prospective cohort study, Confounding, Ferulic acid, Population, Type 2 diabetes, Environmental health, Coronary heart disease, Diabetes mellitus, Internal medicine, Food science, Biology, Endocrinology, Endosperm, Biochemistry, Raw material
- MeSH
- humans, coronary disease, hypertension, diabetes mellitus, type 2, risk factors, prospective studies, dietary fiber, edible grain
4 autores
- Stephen Lillioja🇦🇺🇺🇸 · autor de correspondenciaUniversity of Wollongong; In-Q-Tel; Illawarra Health and Medical Research Institute
- Andrew L. Neal🇬🇧Rothamsted Research
- Linda C Tapsell🇦🇺University of Wollongong; Illawarra Health and Medical Research Institute
- David R. Jacobs🇺🇸University of Minnesota
Resumen
El texto original del estudio, en el idioma en que se publicó.
Higher whole grain cereal intakes are associated with substantially lower risks of type 2 diabetes, coronary heart disease, and hypertension. These reduced risks have been established in large prospective studies that now include millions of person-years of follow-up. We analyze the results of 11 major prospective studies to provide recommendations about whole grain consumption. The following review establishes the amount of whole grains that should ideally be consumed based on prospective evidence; defines the nature of whole grains; identifies that the whole grain evidence is robust and not due to confounding; and provides a detailed assessment of several potential mechanisms for the effect of whole grains on health. We draw the following conclusions. Firstly, to maintain health, 40 grams or more of whole grains should be consumed daily. This is about a bowl of whole grain breakfast cereal daily, but 80% of the population does not achieve this. Secondly, aleurone in bran is a critical grain component generally overlooked in favor of indigestible fiber. Live aleurone cells constitute 50% of millers' bran. They store minerals, protein, and the antioxidant ferulic acid, and are clearly more than just indigestible fiber. Finally, we suggest potential roles for magnesium, zinc, and ferulic acid in the development of chronic disease. If the results of prospective studies were applied to the life-style practices of modern societies there exists the potential for enormous personal health and public financial benefits.
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