Financiado en parte por Fonterra Co-Operative Group
The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials
Gould JF, Smithers LG, Makrides M
The American journal of clinical nutrition · 133 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Children's Health Research Institute
- Empresa
- Fonterra Co-Operative Group
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-01-31 · Am J Clin Nutr · vol. 97 · número 3 · págs. 531–544
- Editorial
- Elsevier BV
- Citado
- 220 citas · más que el 96% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Child Nutrition and Water Access
- Palabras clave
- omega-3 fatty acids, long-chain polyunsaturated fatty acids, maternal supplementation, pregnancy, early childhood cognitive development, visual development, brain development, fish consumption, lactation, child language acquisition, children's motor development
- MeSH
- humans, fatty acids, omega-3, treatment outcome, cognition, pregnancy, visual acuity, dietary supplements, infant, female, randomized controlled trials as topic, infant nutritional physiological phenomena, maternal nutritional physiological phenomena
3 autores
- Jacqueline F. Gould🇦🇺Women's & Children's Health Research Institute
- Lisa Gaye Smithers🇦🇺Women's and Children's Hospital; The University of Adelaide
- Maria Makrides🇦🇺Women's & Children's Health Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Maternal fish consumption during pregnancy has been positively associated with cognitive and visual abilities in the offspring, leading to the hypothesis that maternal omega-3 (n-3) long-chain PUFA (LCPUFA) supplementation improves children's neurologic and visual development.
Objective
The objective was to evaluate the effect of maternal omega-3 LCPUFA supplementation in pregnancy on neurologic and visual development in the offspring.
Design
Five electronic databases were searched. Human randomized controlled trials that supplemented the maternal diet with omega-3 LCPUFAs during pregnancy, or pregnancy and lactation, and that assessed either neurologic or visual development of the offspring were included. Trial quality was assessed, and the results of eligible trials were compared in meta-analyses.
Results
Eleven RCTs involving 5272 participants were included in the review. Most trials had methodologic limitations. No differences in standardized psychometric test scores for cognitive, language, or motor development were observed between the LCPUFA-supplemented and control groups, except for cognitive scores in 2-5-y-old children, in whom supplementation resulted in higher Developmental Standard Scores (mean difference: 3.92; 95% CI: 0.77, 7.08; n = 156; P = 0.01). However, this effect was from 2 trials with a high risk of bias. Because of the variety of visual assessments and age ranges, it was not possible to combine studies with visual outcomes in a meta-analysis, although 6 of the 8 assessments in 5 trials reported no difference between the supplemented and control groups.
Conclusion
The evidence does not conclusively support or refute that omega-3 LCPUFA supplementation in pregnancy improves cognitive or visual development.
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