Antiproliferative activity of the dietary isothiocyanate erucin, a bioactive compound from cruciferous vegetables, on human prostate cancer cells
Melchini A, Traka MH, Catania S, Miceli N, Taviano MF, Maimone P, Francisco M, Mithen RF, Costa C
Nutrition and cancer · 27 citas
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- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-01-01 · Nutr Cancer · vol. 65 · número 1 · págs. 132–138
- Editorial
- Routledge
- Citado
- 42 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Kruppel-like factors research · Glutathione Transferases and Polymorphisms
- Palabras clave
- Cruciferous vegetables, Protein kinase B, Sulforaphane, MAPK/ERK pathway, Cell growth, Cancer research, Kinase, Cyclin-dependent kinase, Prostate cancer, Isothiocyanate, Signal transduction, Cancer, Carcinogenesis, PI3K/AKT/mTOR pathway, Phenethyl isothiocyanate, Chemistry, Pharmacology, Biology, Biochemistry, Medicine, Internal medicine, Cell cycle
- MeSH
- cell line, tumor, humans, vegetables, adenocarcinoma, prostatic neoplasms, sulfides, thiocyanates, isothiocyanates, sulfoxides, extracellular signal-regulated map kinases, anticarcinogenic agents, antineoplastic agents, phytogenic, cell proliferation, dose-response relationship, drug, male, cyclin-dependent kinase inhibitor p21, proto-oncogene proteins c-akt, phosphatidylinositol 3-kinases
9 autores
- Antonietta Melchini🇮🇹🇬🇧University of Messina; Norwich Research Park; Quadram Institute
- Μαρία Τράκα🇬🇧Norwich Research Park; Quadram Institute
- Stefania Catania🇮🇹University of Messina
- Natalizia Miceli🇮🇹University of Messina
- Maria Fernanda Taviano🇮🇹University of Messina
- Patrizia Maimone🇮🇹University of Messina
- Marta Francisco🇪🇸Misión Biológica de Galicia
- Richard F. Mithen🇬🇧Norwich Research Park; Quadram Institute
- Chiara Costa🇮🇹University of Messina
Resumen
El texto original del estudio, en el idioma en que se publicó.
It is becoming increasingly clear that many dietary agents, such as isothiocyanates (ITCs) from cruciferous vegetables, can retard or prevent the process of prostate carcinogenesis. Erucin (ER) is a dietary ITC, which has been recently considered a promising cancer chemopreventive phytochemical. The potential protective activity of ER against prostate cancer was investigated using prostate adenocarcinoma cells (PC3), to analyze its effects on pathways involved in cell growth regulation, such as the cyclin-dependent kinase (CDKs) inhibitor p21(WAF1/CIP1) (p21), phosphatidylinositol-3 kinase/AKT, and extracellular signal-regulated kinases (ERK)1/2 signaling pathways. We have shown for the first time that ER increases significantly p21 protein expression and ERK1/2 phosphorylation in a dose-dependent manner to inhibit PC3 cell proliferation (P ≤ 0.01). Compared to the structurally related sulforaphane, a well-studied broccoli-derived ITC, ER showed lower potency in inhibiting proliferation of PC3 cells, as well as in modulating p21 and pERK1/2 protein levels. Neither of the naturally occurring ITCs was able to affect significantly pAKT protein levels in prostate cells at all concentrations tested (0-25 μM). It is clearly important for the translation of laboratory findings to clinical approaches to investigate in animal and cell studies the molecular mechanisms by which ITCs may exert health promoting effects.
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