Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients
Harris WS, Pottala JV, Varvel SA, Borowski JJ, Ward JN, McConnell JP
Prostaglandins, leukotrienes, and essential fatty acids · 130 citas
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Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-01-31 · Prostaglandins Leukot Essent Fatty Acids · vol. 88 · número 4 · págs. 257–263
- Editorial
- Elsevier BV
- Citado
- 162 citas · más que el 99% de estudios similares · 12.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- Docosahexaenoic acid, Eicosapentaenoic acid, Linoleic acid, Arachidonic acid, Internal medicine, Percentile, Endocrinology, Polyunsaturated fatty acid, Medicine, Fatty acid, Animal science, Physiology, Biology, Biochemistry
- MeSH
- erythrocytes, humans, coronary disease, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, linoleic acid, risk factors, age factors, adolescent, adult, aged, middle aged, child, female, male, young adult
6 autores
- William Stephen Harris🇺🇸 · autor de correspondenciaMedical Diagnostic Laboratories (United States)
- James V. Pottala🇺🇸Medical Diagnostic Laboratories (United States)
- Stephen A. Varvel🇺🇸Medical Diagnostic Laboratories (United States)
- James Borowski🇺🇸Medical Diagnostic Laboratories (United States)
- Jennie N. Ward🇺🇸Medical Diagnostic Laboratories (United States)
- Joseph P. McConnell🇺🇸Medical Diagnostic Laboratories (United States)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The fatty acid (FA) composition of the red blood cell (RBC) has been reported to provide prognostic information regarding risk for coronary heart disease (CHD). In particular, the Omega-3 Index (RBC eicosapentaenoic acid+docosahexaenoic acid, EPA+DHA) has been shown to be independently and inversely related to risk for sudden cardiac death and for acute coronary syndromes. Higher linoleic acid (n-6) and lower trans FA levels have also been associated with improved CHD outcomes. Accordingly, the RBC FA panel has recently been introduced in routine clinical laboratory testing.
Objective
The purpose of this study was to define age- and gender-based norms for RBC FA levels.
Methods
RBC FA profiles from about 160,000 patients (48% from males, 52% from females) were measured at Health Diagnostic Laboratory. These data were used to create age decade and gender-specific norms (percentiles). FA values were expressed as a percent of total identified FA.
Results
Compared to men, women generally had higher C18 trans levels, and between the ages of 10-29 years, they had DHA and lower EPA levels. Among the major FA classes, saturated (41% of total) and trans (∼0.85%) fats did not vary appreciably by age, whereas monounsaturated fats tended to rise slightly. Of the two major n-6 polyunsaturates, arachidonic and linoleic acids, the former was unchanged across decades (16.4% abundance) whereas the latter decreased by about 2 percentage points (13.0-11.1%). The overall median Omega-3 Index was 4.5%, and across the decades it increased by about 1.5 percentage points. The Omega-3 Index and linoleic acid stabilized after age 70.
Conclusion
Whereas RBC saturated, mono- and polyunsaturated FA levels are generally stable across the lifespan, there is a shift in the composition of the latter, with an increase in the Omega-3 Index and a decrease in linoleic acid. Higher DHA and lower EPA levels in younger women is consistent with enhanced conversion of EPA to DHA during the early reproductive years. The availability of RBC FA norms will facilitate research into the relationships between altered FA status and human disease, and will help physicians evaluate the n-3 FA status of their patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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