Red and processed meat intake and risk of colorectal adenomas: a systematic review and meta-analysis of epidemiological studies
Aune D, Chan DS, Vieira AR, Navarro Rosenblatt DA, Vieira R, Greenwood DC, Kampman E, Norat T
Cancer causes & control : CCC · 117 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- World Cancer Research Fund International
- Universidad u hospital
- Wageningen University and Research
Según 2 financiadores declarados.
Publicación
- Publicado
- 2013-02-04 · Cancer Causes Control · vol. 24 · número 4 · págs. 611–627
- Editorial
- Springer Science+Business Media
- Citado
- 169 citas · más que el 90% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 85 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nutritional Studies and Diet · Colorectal Cancer Screening and Detection · Meat and Animal Product Quality
- Palabras clave
- red meat, processed meat, colorectal adenoma, colorectal cancer, dietary intake, cancer risk, nonlinear relationship, meat consumption
- MeSH
- humans, adenoma, colorectal neoplasms, risk factors, epidemiologic studies, meat
8 autores
- Dagfinn Aune🇬🇧 · autor de correspondenciaImperial College London
- Doris S.M. Chan🇬🇧Imperial College London
- Ana Vieira🇬🇧Imperial College London
- Deborah Navarro-Rosenblatt🇬🇧Imperial College London
- Rui Vieira🇬🇧Imperial College London
- Darren Charles Greenwood🇬🇧University of Leeds
- Ellen Kampman🇳🇱Wageningen University & Research
- Teresa Norat🇬🇧Imperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Current evidence indicates that red and processed meat intake increases the risk of colorectal cancer; however, the association with colorectal adenomas is unclear.
Objective
To conduct a systematic review and meta-analysis of epidemiological studies of red and processed meat intake and risk of colorectal adenomas as part of the Continuous Update Project of the World Cancer Research Fund.
Design
PubMed and several other databases were searched for relevant studies from their inception up to 31 December 2011. Summary relative risks (RRs) were estimated using a random effects model.
Results
Nineteen case-control studies and seven prospective studies were included in the analyses. The summary RR per 100 g/day of red meat was 1.27 (95 % CI 1.16-1.40, I (2) = 5 %, n = 16) for all studies combined, 1.20 (95 % CI 1.06-1.36, I (2) = 0 %, n = 6) for prospective studies, and 1.34 (95 % CI 1.12-1.59, I (2) = 31 %, n = 10) for case-control studies. The summary RR per 50 g/day of processed meat intake was 1.29 (95 % CI 1.10-1.53, I (2) = 27 %, n = 10) for all studies combined, 1.45 (95 % CI 1.10-1.90, I (2) = 0 %, n = 2) for prospective studies, and 1.23 (95 % CI 0.99-1.52, I (2) = 37 %, n = 8) for case-control studies. There was evidence of a nonlinear association between red meat (p nonlinearity < 0.001) and processed meat (p nonlinearity = 0.01) intake and colorectal adenoma risk.
Conclusion
These results indicate an elevated risk of colorectal adenomas with intake of red and processed meat, but further prospective studies are warranted.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.