Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes
Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin N
Free radical biology & medicine · 200 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institute for Health Research (NIHR)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2013-02-08 · Free Radic Biol Med · vol. 60 · págs. 89–97
- Editorial
- Elsevier BV
- Citado
- 261 citas · más que el 99% de estudios similares · 13.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention · Blood Pressure and Hypertension Studies
- Palabras clave
- dietary nitrate, beetroot juice, type 2 diabetes, blood pressure, endothelial function, insulin sensitivity, nitrite, nitric oxide, nitrate supplementation, ambulatory blood pressure monitoring, hyperinsulinemic-euglycemic clamp, microvascular function
- MeSH
- endothelium, humans, beta vulgaris, vegetables, cardiovascular diseases, diabetes mellitus, type 2, insulin resistance, nitrates, nitrites, nitric oxide, blood pressure, dietary supplements, aged, middle aged, female, male
6 autores
- Mark Gilchrist🇬🇧 · autor de correspondenciaUniversity of Exeter; NIHR Exeter Clinical Research Facility; Peninsula College of Medicine and Dentistry
- Paul Graham Winyard🇬🇧University of Exeter; NIHR Exeter Clinical Research Facility; Peninsula College of Medicine and Dentistry
- Kunihiko Aizawa🇬🇧University of Exeter; NIHR Exeter Clinical Research Facility; Peninsula College of Medicine and Dentistry
- Christine Anning🇬🇧University of Exeter; NIHR Exeter Clinical Research Facility; Peninsula College of Medicine and Dentistry
- Angela C. Shore🇬🇧University of Exeter; NIHR Exeter Clinical Research Facility; Peninsula College of Medicine and Dentistry
- Nigel Benjamin🇬🇧University of Exeter; NIHR Exeter Clinical Research Facility; Peninsula College of Medicine and Dentistry
Resumen
El texto original del estudio, en el idioma en que se publicó.
Diets rich in green, leafy vegetables have been shown to lower blood pressure (BP) and reduce the risk of cardiovascular disease. Green, leafy vegetables and beetroot are particularly rich in inorganic nitrate. Dietary nitrate supplementation, via sequential reduction to nitrite and NO, has previously been shown to lower BP and improve endothelial function in healthy humans. We sought to determine if supplementing dietary nitrate with beetroot juice, a rich source of nitrate, will lower BP and improve endothelial function and insulin sensitivity in individuals with type 2 diabetes (T2DM). Twenty-seven patients, age 67.2±4.9 years (18 male), were recruited for a double-blind, randomized, placebo-controlled crossover trial. Participants were randomized to begin, in either order, a 2-week period of supplementation with 250ml beetroot juice daily (active) or 250ml nitrate-depleted beetroot juice (placebo). At the conclusion of each intervention period 24-h ambulatory blood pressure monitoring, tests of macro- and microvascular endothelial function, and a hyperinsulinemic isoglycemic clamp were performed. After 2 weeks administration of beetroot juice mean ambulatory systolic BP was unchanged: 134.6±8.4mmHg versus 135.1±7.8mmHg (mean±SD), placebo vs active-mean difference of -0.5mmHg (placebo-active), p=0.737 (95% CI -3.9 to 2.8). There were no changes in macrovascular or microvascular endothelial function or insulin sensitivity. Supplementation of the diet with 7.5mmol of nitrate per day for 2 weeks caused an increase in plasma nitrite and nitrate concentration, but did not lower BP, improve endothelial function, or improve insulin sensitivity in individuals with T2DM.
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