Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial
Belenchia AM, Tosh AK, Hillman LS, Peterson CA
The American journal of clinical nutrition · 213 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-02-13 · Am J Clin Nutr · vol. 97 · número 4 · págs. 774–781
- Editorial
- Elsevier BV
- Citado
- 328 citas · más que el 100% de estudios similares · 29.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · Magnesium in Health and Disease
- Palabras clave
- vitamin D deficiency, vitamin D3 supplementation, insulin resistance, insulin sensitivity, adolescent obesity, 25-hydroxyvitamin D, leptin/adiponectin ratio, adipokines, inflammatory markers, HOMA-IR
- MeSH
- humans, insulin resistance, vitamin d deficiency, obesity, cholecalciferol, insulin, leptin, blood glucose, vitamins, vitamin d, inflammation mediators, body mass index, treatment outcome, dietary supplements, adolescent, child, female, male, adiponectin, adipokines
4 autores
- Anthony M. Belenchia🇺🇸University of Missouri
- Aneesh K. Tosh🇺🇸University of Missouri
- Laura S. Hillman🇺🇸University of Missouri
- Catherine A. Peterson🇺🇸University of Missouri
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Obese adolescents are at a greater risk of vitamin D deficiency because vitamin D is thought to be sequestered by excess adipose tissue. Poor vitamin D status has been associated with a higher prevalence of the metabolic syndrome, type 2 diabetes, or both in adults and adolescents.
Objective
The objective was to determine in obese adolescents the efficacy and safety of 4000 IU vitamin D3/d and whether subsequent increased circulating concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with improved markers of insulin sensitivity and resistance and reduced inflammation.
Design
Obese adolescent patients [n = 35; mean ± SD age: 14.1 ± 2.8 y; BMI (in kg/m(2)): 39.8 ± 6.1; 25(OH)D: 19.6 ± 7.1 ng/mL] were recruited from the University of Missouri Adolescent Diabetes and Obesity Clinic and were randomly assigned to receive either vitamin D3 (4000 IU/d) or placebo as part of their standard care. Anthropometric measurements, inflammatory markers (IL-6, TNF-α, C-reactive protein), adipokines (leptin, adiponectin), fasting glucose, fasting insulin, and HOMA-IR values were measured at baseline and at 2 follow-up visits (3 and 6 mo).
Results
After 6 mo, there were no significant differences in BMI, serum inflammatory markers, or plasma glucose concentrations between groups. Participants supplemented with vitamin D3 had increases in serum 25(OH)D concentrations (19.5 compared with 2.8 ng/mL for placebo; P < 0.001), fasting insulin (-6.5 compared with +1.2 μU/mL for placebo; P = 0.026), HOMA-IR (-1.363 compared with +0.27 for placebo; P = 0.033), and leptin-to-adiponectin ratio (-1.41 compared with +0.10 for placebo; P = 0.045). Inflammatory markers remained unchanged.
Conclusion
The correction of poor vitamin D status through dietary supplementation may be an effective addition to the standard treatment of obesity and its associated insulin resistance. This trial was registered at clinicaltrials.gov as NCT00994396.
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