Caffeine and cognitive decline in elderly women at high vascular risk
Vercambre MN, Berr C, Ritchie K, Kang JH
Journal of Alzheimer's disease : JAD · 46 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NIA NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Institute on Aging (AG15933); National Heart, Lung, and Blood Institute (HL046959); National Institute on Aging (R01AG-015933); National Heart, Lung, and Blood Institute (R01 HL046959)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-04-17 · J Alzheimers Dis · vol. 35 · número 2 · págs. 413–421
- Editorial
- IOS Press
- Citado
- 66 citas · más que el 95% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Coffee research and impacts · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- caffeine, cognitive decline
- MeSH
- humans, cerebrovascular disorders, disease progression, caffeine, vitamins, vitamin b complex, central nervous system stimulants, multivariate analysis, linear models, cohort studies, longitudinal studies, cognition, cognition disorders, neuropsychological tests, aging, dietary supplements, aged, middle aged, female, surveys and questionnaires
4 autores
- Marie‐Noël Vercambre🇫🇷Fondation MGEN pour la Santé Publique
- Claudine Berr🇫🇷Inserm; Université Montpellier 1
- Karen A. Ritchie🇫🇷Inserm; Université Montpellier 1
- Jae Hee Kang🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Persons with vascular disorders are at higher risk of cognitive decline.
Objective
To determine whether caffeine may be associated with cognitive decline reduction in elderly at high vascular risk.
Methods
We included 2,475 women aged 65+ years in the Women's Antioxidant Cardiovascular Study, a randomized trial of antioxidants and B vitamins for cardiovascular disease secondary prevention. We ascertained regular caffeine intake at baseline (1995-1996) using a validated 116 item-food frequency questionnaire. From 1998-2000 to 2005-2006, we administered four telephone cognitive assessments at two-year intervals evaluating global cognition, verbal memory, and category fluency. The primary outcome was the change in global cognitive score, which was the average of the z-scores of all tests. We used generalized linear models for repeated measures that were adjusted for various sociodemographic, health, and lifestyle factors to evaluate the difference in cognitive decline rates across quintiles of caffeine intake.
Results
We observed significantly slower rates of cognitive decline with increasing caffeine intake (p-trend = 0.02). The rate difference between the highest and lowest quintiles of usual caffeine intake (>371 versus <30 mg/day) was equivalent to that observed between those who were 7 years apart in age (p = 0.006). Consumption of caffeinated coffee was significantly related to slower cognitive decline (p-trend = 0.05), but not other caffeinated products (e.g., decaf, tea, cola, chocolate). We conducted interaction analyses and observed stronger associations in women assigned to vitamin B supplementation (p-interaction = 0.02).
Conclusions
Caffeine intake was related to moderately better cognitive maintenance over 5 years in older women with vascular disorders.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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