Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials
Zheng XX, Xu YL, Li SH, Hui R, Wu YJ, Huang XH
The American journal of clinical nutrition · 96 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-02-21 · Am J Clin Nutr · vol. 97 · número 4 · págs. 750–762
- Editorial
- Elsevier BV
- Citado
- 146 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 70 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Tea Polyphenols and Effects · Natural Antidiabetic Agents Studies · Coffee research and impacts
- Palabras clave
- green tea catechins, caffeine, glycemic control, fasting blood glucose, fasting insulin, HbA1c, insulin resistance, glucose metabolism, type 2 diabetes
- MeSH
- humans, camellia sinensis, metabolic diseases, hyperglycemia, insulin resistance, catechin, caffeine, insulin, blood glucose, plant extracts, hypoglycemic agents, phytotherapy, adult, glycated hemoglobin
6 autores
- Xinxin Zheng🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Yan-Lu Xu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Shaohua Li🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Rutai Hui🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Yongjian Wu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Xiaohong Huang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The effect of green tea catechins (GTCs) with or without caffeine on glycemic control is controversial.
Objective
We aimed to identify and quantify the effects of GTCs or GTC-caffeine mixtures on glucose metabolism in adults.
Design
A comprehensive literature search was conducted to identify relevant trials of GTCs with or without caffeine on markers of glycemic control [fasting blood glucose (FBG), fasting blood insulin (FBI), glycated hemoglobin (Hb A1c), and homeostatic model assessment of insulin resistance (HOMA-IR)]. Weighted mean differences were calculated for net changes by using fixed-effects models. Prespecified subgroup analyses were performed to explore the influence of covariates on net changes in FBG and FBI concentrations.
Results
Twenty-two eligible randomized controlled trials with 1584 subjects were identified. Pooled analyses showed that FBG (-1.48 mg/dL; 95% CI: -2.57, -0.40 mg/dL) decreased significantly with GTCs with or without caffeine, whereas FBI (0.04 μU/mL; 95% CI: -0.36, 0.45 μU/mL), Hb A1c (-0.04%; 95% CI: -0.15, 0.08%), and HOMA-IR (-0.05; 95% CI: -0.37, 0.26) did not. Subgroup analyses indicated that the glucose-lowering effect was apparent when the duration of follow-up was over a median of 12 wk. Overall, no significant heterogeneity was detected for FBG, FBI, Hb A1c, or HOMA-IR.
Conclusions
The meta-analysis showed that the administration of GTCs with or without caffeine resulted in a significant reduction in FBG. The limited data available on GTCs did not support a positive effect on FBI, Hb A1c, or HOMA-IR. Thus, more large and well-designed trials are needed in the future. This trial was registered at http://www.crd.york.ac.uk/prospero as CRD42012002139.
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