Proportion of neural tube defects attributable to known risk factors
Agopian AJ, Tinker SC, Lupo PJ, Canfield MA, Mitchell LE, National Birth Defects Prevention Study
Birth defects research. Part A, Clinical and molecular teratology · 80 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Centers for Disease Control and Prevention
- Gobierno
- Intramural CDC HHS
- Gobierno
- NCBDD CDC HHS
- Subvenciones
- Centers for Disease Control and Prevention (U01DD000494); National Institutes of Health (CC999999)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2012-11-27 · Birth Defects Res A Clin Mol Teratol · vol. 97 · número 1 · págs. 42–46
- Citado
- 129 citas · más que el 94% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 17 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Folate and B Vitamins Research · Spinal Dysraphism and Malformations · Fetal and Pediatric Neurological Disorders
- Palabras clave
- Anencephaly, Attributable risk, Medicine, Spina bifida, Population, Neural tube, Obesity, Risk factor, Pregnancy, Offspring, Ethnic group, Neural tube defect, Pediatrics, Environmental health, Obstetrics, Internal medicine, Fetus, Genetics, Biology
- MeSH
- humans, anencephaly, spinal dysraphism, pregnancy complications, obesity, risk assessment, risk factors, mothers, maternal exposure, causality, pregnancy, databases, factual, adult, united states, female, male, hispanic or latino
6 autores
- A. J. Agopian🇺🇸Center for Human Genetics; The University of Texas Health Science Center at Houston
- Sarah C. Tinker🇺🇸Centers for Disease Control and Prevention; National Center on Birth Defects and Developmental Disabilities
- Philip J. Lupo🇺🇸The University of Texas Health Science Center at Houston
- Mark A. Canfield🇺🇸Texas Department of State Health Services
- Laura E. Mitchell🇺🇸 · autor de correspondenciaThe University of Texas Health Science Center at Houston
- and the National Birth Defects Prevention Study
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recognized risk factors for neural tube defects (NTDs) poorly predict population-level NTD risk. However, the proportion of NTDs that can be attributed to these risk factors is uncertain.
Methods
To determine the proportion of NTD cases that is attributable to known or suspected risk factors (i.e., female infant sex, family history of NTDs, and maternal Hispanic ethnicity, obesity, pregestational diabetes, gestational diabetes, low dietary folate intake, lack of folic acid supplementation, anticonvulsant use, and hot tub or sauna use), we estimated the adjusted population attributable fraction (aAF) for each factor, using the method of Eide and Geffler and data from the National Birth Defects Prevention Study.
Results
Our analyses of these data indicate that the proportion of cases of spina bifida and anencephaly that can be attributed to known risk factors is 28% and 44%, respectively. For spina bifida, the factor with the greatest attributable fraction was maternal obesity (aAF, 10%), whereas for anencephaly it was Hispanic ethnicity (aAF, 15%).
Conclusion
Our analyses indicate that known risk factors account for <50% of NTD cases. Hence, the majority of NTD cases are attributable to, as yet, unidentified factors. These findings highlight the need for continued research to identify genetic and additional nongenetic risk factors for NTDs. Further, these findings suggest that strategies that aim to reduce the risk of NTDs associated with maternal Hispanic ethnicity and obesity may have the greatest impact on the population prevalence of these conditions.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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