Magnesium supplementation reduces postoperative arrhythmias after cardiopulmonary bypass in pediatrics: a metaanalysis of randomized controlled trials
Lee HY, Ghimire S, Kim EY
Pediatric cardiology · 11 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-02-26 · Pediatr Cardiol · vol. 34 · número 6 · págs. 1396–1403
- Editorial
- Springer Science+Business Media
- Citado
- 14 citas · más que el 64% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiac and Coronary Surgery Techniques · Magnesium in Health and Disease · Congenital Heart Disease Studies
- Palabras clave
- magnesium supplementation, postoperative arrhythmia, cardiopulmonary bypass, pediatric cardiac surgery, arrhythmia prevention
- MeSH
- humans, postoperative complications, magnesium, cardiopulmonary bypass, incidence, dietary supplements, child, arrhythmias, cardiac, randomized controlled trials as topic, global health
3 autores
- Heeyoung Lee🇰🇷Chungnam National University
- Saurav Ghimire🇰🇷Chungnam National University
- Eun Young Kim🇰🇷 · autor de correspondenciaChung-Ang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Postoperative arrhythmia (POA) is the most common complication encountered after cardiopulmonary bypass (CPB). The preventive effect of magnesium in POA has been confirmed by metaanalyses in adults, but less is known in pediatric patients. A metaanalysis of published trials was conducted to examine the efficacy of magnesium supplementation in POA prevention among pediatric patients undergoing CPB. Relevant trials were identified from electronic databases (Medline, Embase, Web of Science, and Cochrane library). Pooled relative risk (RR) and 95 % confidence intervals (CI) were calculated using Mantel-Haenszel random-effects models, and heterogeneity was determined qualitatively according to I (2) and chi-squared statistical analyses. Among 121 potentially relevant studies, five randomized controlled trials met the inclusion criteria, resulting in a pooled total of 348 participants. Compared with placebo, magnesium supplementation decreased the incidence of arrhythmia after CPB in pediatric patients by 66 % (RR, 0.34; 95 % CI, 0.18-0.65; P = 0.001), with no heterogeneity between trials (heterogeneity P = 0.68; I (2) = 0 %). Magnesium supplementation significantly reduces the incidence of postoperative arrhythmias in pediatric patients undergoing CPB. Although the findings encourage the use of magnesium as an alternative to postoperative arrhythmias after CPB in pediatric patients, higher-quality randomized clinical trials are necessary before the findings can be generalized.
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