Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants
Kunutsor SK, Apekey TA, Steur M
European journal of epidemiology · 168 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-03-01 · Eur J Epidemiol · vol. 28 · número 3 · págs. 205–221
- Editorial
- Springer Science+Business Media
- Citado
- 261 citas · más que el 95% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 85 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Blood Pressure and Hypertension Studies · Nutritional Studies and Diet
- Palabras clave
- vitamin D, hypertension, 25-hydroxyvitamin D, vitamin D intake, hypertension incidence, dose-response relationship, vitamin D status, hypertension prevention
- MeSH
- humans, hypertension, vitamin d, odds ratio, risk factors, prospective studies, predictive value of tests, blood pressure, dose-response relationship, drug, dietary supplements, biomarkers
3 autores
- Setor Kwadzo Kunutsor🇬🇧 · autor de correspondenciaUniversity of Leeds; University of Cambridge
- Tanefa Antoinette Apekey🇬🇧University of Leeds
- Marinka Steur🇬🇧University of Cambridge
Resumen
El texto original del estudio, en el idioma en que se publicó.
The evidence on the association between baseline vitamin D status and risk of incident hypertension in general populations is limited and has not been reliably quantified. We conducted a systematic review and meta-analysis of published prospective studies evaluating the associations of baseline vitamin D status (circulating 25-hydroxyvitamin D [25(OH)D] levels and dietary vitamin D intake) with risk of hypertension. Eligible studies were identified in a literature search of MEDLINE, EMBASE, and Web of Science up to November 2012. Pooled relative risks (RRs) with 95% confidence intervals were calculated using random effects models. Generalized least-squares trend estimation was used to assess dose-response relationships. Of the 2,432 articles reviewed for eligibility, eight unique prospective cohorts with aggregate data on 283,537 non-overlapping participants and 55,816 incident hypertension cases were included. The RRs (95% CIs) for hypertension in a comparison of extreme thirds of baseline levels of vitamin D were 0.70 (0.58, 0.86) for seven studies that measured blood 25(OH) D levels and 1.00 (0.95, 1.05) for four studies that assessed dietary vitamin D intake. The pooled RR of incident hypertension per 10 ng/mL increment in baseline 25(OH)D levels was 0.88 (0.81, 0.97) in dose-response analysis. Evidence was lacking of heterogeneity among studies that measured blood 25(OH) D levels and those that assessed dietary vitamin D status. Studies are needed to determine whether the association of vitamin D with hypertension represents a causal association and also to determine whether vitamin D therapy may be beneficial in the prevention or the treatment of hypertension.
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