The effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exercise
Sanchez-Gonzalez MA, Koutnik AP, Ramirez K, Wong A, Figueroa A
American journal of hypertension · 24 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-12-27 · Am J Hypertens · vol. 26 · número 4 · págs. 518–526
- Editorial
- Oxford University Press
- Citado
- 36 citas · más que el 76% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology · Biochemical effects in animals
- Palabras clave
- citrulline, cold exposure, isometric handgrip exercise, pulse wave analysis, augmentation index, blood pressure, wave reflection, applanation tonometry, cardioprotection, dietary supplementation
- MeSH
- brachial artery, humans, citrulline, hand strength, exercise, blood pressure, adult, male, cold temperature, vascular stiffness, arterial pressure, pulse wave analysis
5 autores
- Marcos A. Sanchez‐Gonzalez🇺🇸Florida State University
- Andrew Paul Koutnik🇺🇸Florida State University
- K. Ramirez🇺🇸Florida State University
- Alexei Wong🇺🇸Florida State University
- Arturo Figueroa🇺🇸Florida State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Supplementation with L-citrulline (L-cit) has shown attenuating effects on blood pressure (BP) and pulse-wave-reflection responses (augmentation index (AIx)) to local exposure to cold, but the potential cardioprotective effects of L-cit during whole-body cold exposure with concurrent exercise are poorly understood. We hypothesized that L-cit would attenuate the BP and AIx responses to cold exposure and isometric handgrip (IHG) exercise.
Methods
Sixteen healthy males with a mean age of 23±3 years volunteered for a study of the effect of L-cit on the BP and AIx responses to cold exposure and IHG exercise. Experiments were conducted inside an environmental chamber in cold conditions (4 ºC). Radial waveforms were obtained in duplicates and averaged through applanation tonometry. After 5 minutes of measurements made at rest in the supine position (RES), after the finalization of the exercise about the subjects were evaluated in non exercise condition that were basically the same as the RES. After initial measurements in cold conditions, subjects were randomized to receive either a placebo (Maltodextrin, PL) or L-cit (100mg/kg) for 14 days, followed by a 14-day washout period and then a 14-day regimen of the other agent. Subjects were re-evaluated after each treatment period.
Results
At RES, there was a significant treatment-by-time interaction for brachial systolic BP (BSBP; P < 0.01), aortic systolic BP (ASBP; P < 0.01), and AIx (P < 0.05), such that L-cit decreased BSBP (-11±2mm Hg; P < 0.01), ASBP (-10±2mm Hg; P < 0.05), and AIx (-2±2%; P < 0.05) as compared with their respective values before the intervention. During IHG, BSBP, ASBP, and AIx were increased (P < 0.05) as compared with their values at RES, but these responses were unaffected by either of the study treatments.
Conclusions
L-citrulline may be a feasible adjuvant treatment for decrease the BP and AIx responses induced by cold. Further research is warranted to evaluate the impact of cold exposure and exercise on cardiovascular risk in clinical populations.
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