A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers
Del Bó C, Riso P, Campolo J, Møller P, Loft S, Klimis-Zacas D, Brambilla A, Rizzolo A, Porrini M
Nutrition research (New York, N.Y.) · 72 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-02-01 · Nutr Res · vol. 33 · número 3 · págs. 220–227
- Editorial
- Elsevier BV
- Citado
- 113 citas · más que el 98% de estudios similares · 7.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Exercise and Physiological Responses · Pomegranate: compositions and health benefits
- Palabras clave
- blueberry, Vaccinium corymbosum, anthocyanins, oxidative stress, DNA damage, antioxidant defense, vascular function, nitric oxide, peripheral arterial function, hydrogen peroxide-induced DNA damage, blood mononuclear cells
- MeSH
- blood vessels, endothelium, vascular, leukocytes, mononuclear, humans, fruit, dna damage, hydrogen peroxide, nitric oxide, anthocyanins, antioxidants, phytotherapy, diet, cross-over studies, oxidative stress, male, young adult, biomarkers, blueberry plants
9 autores
- Cristian Del Bo’🇮🇹University of Milan
- Patrizia Riso🇮🇹 · autor de correspondenciaUniversity of Milan
- Jonica Campolo🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
- Peter Möller🇩🇰University of Copenhagen
- Steffen H Loft🇩🇰University of Copenhagen
- Dorothy J. Klimis‐Zacas🇺🇸University of Maine
- Ada Brambilla
- A. Rizzolo
- Marisa Porrini🇮🇹University of Milan
Resumen
El texto original del estudio, en el idioma en que se publicó.
It has been suggested that anthocyanin-rich foods may exert antioxidant effects and improve vascular function as demonstrated mainly in vitro and in the animal model. Blueberries are rich sources of anthocyanins and we hypothesized that their intake could improve cell protection against oxidative stress and affect endothelial function in humans. The aim of the study was to investigate the effect of one portion (300 g) of blueberries on selected markers of oxidative stress and antioxidant protection (endogenous and oxidatively induced DNA damage) and of vascular function (changes in peripheral arterial tone and plasma nitric oxide levels) in male subjects. In a randomized cross-over design, separated by a wash out period ten young volunteers received one portion of blueberries ground by blender or one portion of a control jelly. Before and after consumption (at 1, 2, and 24 hours), blood samples were collected and used to evaluate anthocyanin absorption (through mass spectrometry), endogenous and H(2)O(2)-induced DNA damage in blood mononuclear cells (through the comet assay), and plasma nitric oxide concentrations (through a fluorometric assay). Peripheral arterial function was assessed by means of Endo-PAT 2000. Blueberries significantly reduced (P < .01) H(2)O(2)-induced DNA damage (-18%) 1 hour after blueberry consumption compared to control. No significant differences were observed for endogenous DNA damage, peripheral arterial function and nitric oxide levels after blueberry intake. In conclusion, one portion of blueberries seems sufficient to improve cell antioxidant defense against DNA damage, but further studies are necessary to understand their role on vascular function.
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