Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies
Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O'Beirne M, Rabi DM
BMJ (Clinical research ed.) · 475 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Calgary
- Organización sin fines de lucro
- Canadian Foundation for Healthcare Improvement
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Division of Materials Research
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-03-26 · BMJ · vol. 346 · número mar26 4 · pág. f1169
- Citado
- 726 citas · más que el 100% de estudios similares · 11.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · Gestational Diabetes Research and Management · Birth, Development, and Health
- Palabras clave
- 25-hydroxyvitamin D, vitamin D insufficiency, pregnancy outcomes, gestational diabetes mellitus, preeclampsia, bacterial vaginosis, small for gestational age, birth weight, cesarean section, neonatal outcomes, maternal serum vitamin D
- MeSH
- humans, pregnancy complications, vitamin d deficiency, vitamin d, pregnancy outcome, pregnancy, infant, newborn, female
6 autores
- Fariba Aghajafari🇨🇦University of Calgary
- Tharsiya Nagulesapillai🇨🇦University of Calgary
- Paul Everett Ronksley🇨🇦University of Calgary
- Suzanne Tough🇨🇦University of Calgary
- Maeve O’Beirne🇨🇦University of Calgary
- Doreen M. Rabi🇨🇦 · autor de correspondenciaUniversity of Calgary
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables.
Design
Systematic review and meta-analysis.
Data sources
Medline (1966 to August 2012), PubMed (2008 to August 2012), Embase (1980 to August 2012), CINAHL (1981 to August 2012), the Cochrane database of systematic reviews, and the Cochrane database of registered clinical trials.
Study selection
Studies reporting on the association between serum 25-OHD levels during pregnancy and the outcomes of interest (pre-eclampsia, gestational diabetes, bacterial vaginosis, caesarean section, small for gestational age infants, birth weight, birth length, and head circumference).
Data extraction
Two authors independently extracted data from original research articles, including key indicators of study quality. We pooled the most adjusted odds ratios and weighted mean differences. Associations were tested in subgroups representing different patient characteristics and study quality.
Results
3357 studies were identified and reviewed for eligibility. 31 eligible studies were included in the final analysis. Insufficient serum levels of 25-OHD were associated with gestational diabetes (pooled odds ratio 1.49, 95% confidence interval 1.18 to 1.89), pre-eclampsia (1.79, 1.25 to 2.58), and small for gestational age infants (1.85, 1.52 to 2.26). Pregnant women with low serum 25-OHD levels had an increased risk of bacterial vaginosis and low birthweight infants but not delivery by caesarean section.
Conclusion
Vitamin D insufficiency is associated with an increased risk of gestational diabetes, pre-eclampsia, and small for gestational age infants. Pregnant women with low 25-OHD levels had an increased risk of bacterial vaginosis and lower birth weight infants, but not delivery by caesarean section.
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