Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies
Jiang W, Wu Y, Jiang X
Gynecologic oncology · 65 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-03-25 · Gynecol Oncol · vol. 129 · número 3 · págs. 620–629
- Editorial
- Elsevier BV
- Citado
- 110 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Cancer Risks and Factors · Nutritional Studies and Diet
- Palabras clave
- coffee consumption, caffeine consumption, breast cancer risk, decaffeinated coffee, postmenopausal women, BRCA1 mutation carriers, dose-response relationship
- MeSH
- humans, breast neoplasms, caffeine, case-control studies, postmenopause, dose-response relationship, drug, mutation, genes, brca1, coffee, female
3 autores
- Wenjie Jiang🇨🇳 · autor de correspondenciaQingdao University
- Yili Wu🇨🇳 · autor de correspondenciaQingdao University
- Xiubo Jiang🇨🇳 · autor de correspondenciaQingdao University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We conducted an updated meta-analysis to summarize the evidence from published studies regarding the association of coffee and caffeine intake with breast cancer risk.
Methods
Pertinent studies were identified by a search of PubMed and by reviewing the reference lists of retrieved articles. The fixed or random effect model was used based on heterogeneity test. The dose-response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression.
Results
37 published articles, involving 59,018 breast cancer cases and 966,263 participants, were included in the meta-analysis. No significant association was found between breast cancer risk and coffee (RR=0.97, P=0.09), decaffeinated coffee (RR=0.98, P=0.55) and caffeine (RR=0.99, P=0.73), respectively. And the association was still not significant when combining coffee and caffeine (coffee/caffeine) (RR=0.97, P=0.09). However, an inverse association of coffee/caffeine with breast cancer risk was found for postmenopausal women (RR=0.94, P=0.02), and a strong and significant association of coffee with breast cancer risk was found for BRCA1 mutation carriers (RR=0.69, P<0.01). A linear dose-response relationship was found for breast cancer risk with coffee and caffeine, and the risk of breast cancer decreased by 2% (P=0.05) for every 2 cups/day increment in coffee intake, and 1% (P=0.52) for every 200mg/day increment in caffeine intake, respectively.
Conclusions
Findings from this meta-analysis suggested that coffee/caffeine might be weakly associated with breast cancer risk for postmenopausal women, and the association for BRCA1 mutation carriers deserves further investigation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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