Effect of magnesium supplementation on carotid intima-media thickness and flow-mediated dilatation among hemodialysis patients: a double-blind, randomized, placebo-controlled trial
Mortazavi M, Moeinzadeh F, Saadatnia M, Shahidi S, Shahidi S, McGee JC, Minagar A
European neurology · 73 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Vice Chancellor for Research and Technology, Kerman University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2013-01-01 · Eur Neurol · vol. 69 · número 5 · págs. 309–316
- Editorial
- Karger Publishers
- Citado
- 90 citas · más que el 94% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Parathyroid Disorders and Treatments
- Palabras clave
- magnesium supplementation, hemodialysis, carotid intima-media thickness, flow-mediated dilation, endothelial function, C-reactive protein, atherosclerosis, vascular calcification, parathyroid hormone, serum calcium and phosphorus, magnesium oxide
- MeSH
- brachial artery, carotid arteries, humans, kidney diseases, magnesium, renal dialysis, dilatation, analysis of variance, regression analysis, follow-up studies, double-blind method, adult, aged, middle aged, female, male, carotid intima-media thickness
6 autores
- Mojgan Mortazavi🇮🇷Isfahan University of Medical Sciences
- Firouzeh Moeinzadeh
- Mohammad Saadatnia🇮🇷Isfahan University of Medical Sciences
- Shahrzad Shahidi
- Jeanie C. McGee🇺🇸Louisiana State University Health Sciences Center Shreveport
- Alireza Minagar🇺🇸Louisiana State University Health Sciences Center Shreveport
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
The aim of the present study was to determine the efficacy of oral magnesium (Mg) supplementation on endothelial function through evaluation of carotid intima-media thickness (cIMT), brachial artery flow-mediated dilatation (FMD), and C-reactive protein (CRP) among hemodialysis (HD) patients.
Methods
This randomized, controlled, double-blind clinical trial consisted of 54 patients on HD. One group was treated orally with 440 mg of Mg oxide 3 times per week for 6 months (n = 29). The control group (n = 25) was given placebo using the same administration protocol. cIMT, FMD, serum calcium levels, phosphorus, lipid, CRP, and bicarbonate were measured at baseline and at 6 months in both groups.
Results
At 6 months, cIMT was significantly decreased in the Mg group (0.84 ± 0.13 mm at baseline and 0.76 ± 0.13 mm at 6 months, p = 0.001). However, in the placebo group, cIMT was significantly increased (0.73 ± 0.13 and 0.79 ± 0.12 mm, respectively, p = 0.003). When hypertension, diabetes mellitus, smoking, hyperlipidemia, and systemic lupus erythematosus were controlled for in the analysis, the effect of Mg remained significant in both groups (p = 0.000).
Conclusion
Our results indicate that Mg might not improve endothelial function (CRP level and FMD) and that a decreased cIMT as a marker of atherosclerosis may be due to the inhibition of calcification through the regulation parathormone, calcium, and phosphorus.
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