Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis
Wu QJ, Xie L, Zheng W, Zheng W, Vogtmann E, Li HL, Yang G, Ji BT, Gao YT, Shu XO, Xiang YB
Annals of oncology : official journal of the European Society for Medical Oncology · 55 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Vanderbilt University
- Universidad u hospital
- University of Alabama at Birmingham
- Universidad u hospital
- University of Alabama
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- Fogarty International Center
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- Fogarty International Center, NIH, through an R24 Training Grant
- Gobierno
- United States National Institutes of Health
- Gobierno
- State Key Project Specialized for Infectious Diseases of China
- Gobierno
- FIC NIH HHS
- Gobierno
- the National Institutes of Health
- Subvenciones
- National Cancer Institute (R01-CA82729); Fogarty International Center (R24-TW007988); National Cancer Institute (5R25CA047888); National Cancer Institute (R37-CA070867); National Heart, Lung, and Blood Institute (R01 HL095931); Fogarty International Center (R24TW007988-5); National Institutes of Health (R01-CA82729); National Institutes of Health (R24TW007988); National Institutes of Health (R37CA070867); National Institutes of Health (5R25 CA047888); National Institutes of Health (CA047888); National Institutes of Health (R01HL095931)
Según 14 financiadores declarados.
Publicación
- Publicado
- 2013-04-04 · Ann Oncol · vol. 24 · número 7 · págs. 1918–1924
- Editorial
- Elsevier BV
- Citado
- 74 citas · más que el 80% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Lung Cancer Diagnosis and Treatment · Global Cancer Incidence and Screening
- Palabras clave
- cruciferous vegetables, lung cancer, never smokers, dietary intake, chemoprevention, Shanghai Women's Health Study, Chinese women
- MeSH
- humans, brassicaceae, lung neoplasms, diet, incidence, proportional hazards models, risk, prospective studies, female
10 autores
- Qi‐Jun Wu🇨🇳Shanghai Jiao Tong University; Fudan University; Renji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Lu Xie🇨🇳Shanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Wei Zheng🇺🇸Vanderbilt University; Vanderbilt-Ingram Cancer Center
- Emily Vogtmann🇺🇸University of Alabama at Birmingham
- H.L. Li🇨🇳Shanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Gong Yang🇺🇸Vanderbilt University; Vanderbilt-Ingram Cancer Center
- Bu‐Tian Ji🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Yu‐Tang Gao🇨🇳Shanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute
- Xiao‐Ou Shu🇺🇸Vanderbilt University; Vanderbilt-Ingram Cancer Center
- Yong‐Bing Xiang🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; Renji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological studies evaluating the association between cruciferous vegetables (CVs) intake and female lung cancer risk have produced inconsistent results.
Patients and methods
This study followed 74 914 Chinese women aged 40-70 years who participated in the Shanghai Women's Health Study. CV intake was assessed through a validated food-frequency questionnaire (FFQ) at baseline and reassessed during follow-up. Hazard ratios (HRs) and 95% confidence interval (CIs) were estimated by using Cox proportional hazards models. Furthermore, we carried out a meta-analysis of all observational studies until December 2011.
Results
After excluding the first 2 years of follow-up, 417 women developed lung cancer over a mean of 11.1 years of follow-up. An inverse association of borderline statistical significance was observed between CV consumption and female lung cancer risk, with HR for the highest compared with the lowest quartiles of 0.73 (95% CI 0.54-1.00, P trend = 0.1607). The association was strengthened in analyses restricting to never smokers, with the corresponding HR of 0.59 (95% CI 0.40-0.87, P trend = 0.0510). The finding of an inverse association between CV intake and lung cancer risk in women was supported by our meta-analysis of 10 included studies.
Conclusions
Our study suggests that CV consumption may reduce the risk of lung cancer in women, particularly among never smokers.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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