Creatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trial
Alves CR, Santiago BM, Lima FR, Otaduy MC, Calich AL, Tritto AC, de Sá Pinto AL, Roschel H, Leite CC, Benatti FB, Bonfá E, Gualano B
Arthritis care & research · 45 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-04-01 · Arthritis Care Res (Hoboken) · vol. 65 · número 9 · págs. 1449–1459
- Editorial
- Wiley
- Citado
- 73 citas · más que el 89% de estudios similares · 2.8× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Fibromyalgia and Chronic Fatigue Syndrome Research · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- creatine supplementation, creatine monohydrate, fibromyalgia, muscle strength, muscle function, dietary intervention
- MeSH
- humans, fibromyalgia, creatine, phosphocreatine, double-blind method, dietary supplements, adult, middle aged, female
12 autores
- Christiano R. R. Alves🇧🇷Universidade de São Paulo
- Bianca Marques Santiago🇧🇷Universidade de São Paulo
- Fernanda Rodrigues Lima🇧🇷Universidade de São Paulo
- Maria Concepción García Otaduy🇧🇷Universidade de São Paulo
- Ana Luísa Calich🇧🇷Universidade de São Paulo
- Aline C. Tritto🇧🇷Universidade de São Paulo
- Ana Lúcia de Sá Pinto🇧🇷Universidade de São Paulo
- Hamilton Roschel🇧🇷Universidade de São Paulo
- Claudia Costa Leite🇧🇷Universidade de São Paulo
- Fabiana Braga Benatti🇧🇷Universidade de São Paulo
- Eloísa Bonfá🇧🇷Universidade de São Paulo
- Bruno Gualano🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate the efficacy and safety of creatine supplementation in fibromyalgia patients.
Methods
A 16-week, randomized, double-blind, placebo-controlled, parallel-group trial was conducted. Fibromyalgia patients were randomly assigned to receive either creatine monohydrate or placebo in a double-blind manner. The patients were evaluated at baseline and after 16 weeks. Muscle function, aerobic conditioning, cognitive function, quality of sleep, quality of life, kidney function, and adverse events were assessed. Muscle phosphorylcreatine content was measured through (31) P magnetic resonance spectroscopy.
Results
After the intervention, the creatine group presented higher muscle phosphorylcreatine content when compared with the placebo group (+80.3% versus -2.7%; P = 0.04). Furthermore, the creatine group presented greater muscle strength than the placebo group in the leg press and chest press exercises (+9.8% and +1.2% for creatine versus -0.5% and -7.2% for placebo, respectively; P = 0.02 and P = 0.002, respectively). Isometric strength was greater in the creatine group than in the placebo group (+6.4% versus -3.2%; P = 0.007). However, no general changes were observed in aerobic conditioning, pain, cognitive function, quality of sleep, and quality of life. Food intake remained unaltered and no side effects were reported.
Conclusion
Creatine supplementation increased intramuscular phosphorylcreatine content and improved lower- and upper-body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients.
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