Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients
Breslavsky A, Frand J, Matas Z, Boaz M, Barnea Z, Shargorodsky M
Clinical nutrition (Edinburgh, Scotland) · 104 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-02-27 · Clin Nutr · vol. 32 · número 6 · págs. 970–975
- Editorial
- Elsevier BV
- Citado
- 148 citas · más que el 99% de estudios similares · 10.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- vitamin D supplementation, type 2 diabetes, augmentation index, glucose homeostasis, adiponectin, leptin, insulin resistance, cardiovascular risk, 25-hydroxyvitamin D, leptin/adiponectin ratio
- MeSH
- arteries, humans, diabetes mellitus, type 2, insulin resistance, insulin, leptin, blood glucose, vitamin d, hypoglycemic agents, body mass index, administration, oral, linear models, double-blind method, homeostasis, dose-response relationship, drug, dietary supplements, aged, middle aged, female, male, adiponectin
6 autores
- Anna Breslavsky🇮🇱Wolfson Medical Center
- Jacob Frand🇮🇱Wolfson Medical Center
- Zipora Matas🇮🇱Wolfson Medical Center
- Mona Boaz🇮🇱Tel Aviv University; Wolfson Medical Center
- Zvi Barnea🇮🇱Wolfson Medical Center
- Marina Shargorodsky🇮🇱 · autor de correspondenciaTel Aviv University; Wolfson Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Vitamin D supplementation has the potential to alleviate the cardiovascular damage in diabetic patients. The present study was designed to evaluate long term impact of high doses of vitamin D on arterial properties, glucose homeostasis, adiponectin and leptin in patients with type 2 diabetes mellitus.
Methods and results
In randomized, placebo-controlled study 47 diabetic patients were assigned into two groups: Group 1 received oral daily supplementation with vitamin D at a dose of 1000 U/day for 12 months. Group 2 received matching placebo capsules. Blood sampling for metabolic parameters, including fasting glucose, lipid profile, HbA1C, insulin, hs-CRP, 25 OH Vit D, adiponectin and leptin was performed at baseline and at the end of the study. Insulin resistance was assessed by homeostasis model assessment (HOMA-IR). Central aortic augmentation index (AI) was evaluated using SphygmoCor.
Results
The two groups were similar at baseline in terms of hemodynamic parameters. After 12 months, AI decreased significantly during the treatment period in patients received vitamin D (p < 0.0001) and did not change in placebo group. Glucose homeostasis parameters, leptin as well as leptin adiponectin ratio did not change in both groups. 25 OH Vit D level significantly increased (p = 0.022) and circulating adiponectin marginally increased (p = 0.065) during 12 month treatment period in active treatment and did not change in placebo group.
Conclusions
High doses of vitamin D supplementation in diabetic patients was associated with significant decrease in AI during one year treatment. This beneficial vascular effect was not associated with improvement in glucose homeostasis parameters.
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