Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels - results from a randomized trial
Wamberg L, Kampmann U, Stødkilde-Jørgensen H, Rejnmark L, Pedersen SB, Richelsen B, Richelsen B, Richelsen B
European journal of internal medicine · 158 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Aarhus Universitetshospital
Según 1 financiador declarado.
Publicación
- Publicado
- 2013-04-06 · Eur J Intern Med · vol. 24 · número 7 · págs. 644–649
- Editorial
- Elsevier BV
- Citado
- 218 citas · más que el 99% de estudios similares · 13.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, vitamin D deficiency, 25-hydroxyvitamin D, obesity, body fat distribution, visceral adipose tissue, subcutaneous adipose tissue, intrahepatic lipid, intramyocellular lipid, insulin resistance, blood pressure, plasma lipids, inflammation, C-reactive protein, parathyroid hormone, metabolic risk factors
- MeSH
- adipose tissue, humans, metabolic diseases, insulin resistance, vitamin d deficiency, obesity, inflammation, vitamins, vitamin d, placebos, magnetic resonance imaging, treatment outcome, risk factors, double-blind method, adolescent, adult, middle aged, female, male, young adult
6 autores
- Louise Wamberg🇩🇰 · autor de correspondenciaAarhus University; Aarhus University Hospital
- Ulla Kampmann🇩🇰Aarhus University; Aarhus University Hospital
- Hans Stødkilde‐Jørgensen🇩🇰Aarhus University; Aarhus University Hospital
- Lars Rejnmark🇩🇰Aarhus University; Aarhus University Hospital
- Steen B. Pedersen🇩🇰Aarhus University; Aarhus University Hospital
- Bjørn Richelsen🇩🇰Aarhus University; Aarhus University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low plasma 25-hydroxy-vitamin D (25OHD) is associated with obesity. Vitamin D (VD) may be implicated in obesity and its complications such as insulin resistance, hypertension, and low-grade inflammation. We investigated the effects of VD supplementation on fat distribution and on obesity complications in obese adults with low plasma levels of 25OHD.
Methods
In a double-blind design 52 subjects aged 18 to 50years with BMI>30kg/m(2) and plasma 25OHD <50nmol/l were randomized to 26weeks of treatment with 7000IU of VD daily or placebo. Body composition was assessed by DXA and subcutaneous (SAT) and visceral adipose tissue (VAT), intrahepatic (IHL) and intramyocellular lipids (IMCL) were evaluated by magnetic resonance imaging and magnetic resonance spectroscopy. Insulin resistance (HOMA-IR), blood pressure, plasma lipids, and circulating inflammatory markers were also investigated.
Results
VD treatment increased mean plasma levels of 25OHD from 33nmol/l to 110nmol/l (P<0.0001) and decreased median parathyroid hormone levels from 5.3 to 4.5pmol/l (P<0.01) in the intervention group. Treatment did not change body fat, SAT, VAT, IHL, or IMCL compared with placebo. Neither did treatment affect HOMA, blood pressure, plasma lipids or any of several inflammatory markers investigated including hsCRP.
Conclusion
Increasing 25OHD levels by VD treatment for 26weeks have no effects on obesity complications in obese adults with low baseline plasma 25OHD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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