Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury
Barker T, Henriksen VT, Martins TB, Hill HR, Kjeldsberg CR, Schneider ED, Dixon BM, Weaver LK
Nutrients · 95 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Universidad u hospital
- Intermountain Healthcare
- Organización sin fines de lucro
- Intermountain Research and Medical Foundation
- Empresa
- ARUP Institute for Clinical and Experimental Pathology
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-04-17 · Nutrients · vol. 5 · número 4 · págs. 1253–1275
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 129 citas · más que el 99% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 104 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Vitamin D Research Studies · Muscle metabolism and nutrition
- Palabras clave
- 25-hydroxyvitamin D, vitamin D status, high-intensity exercise, isometric force, interferon-gamma, IL-4, albumin, muscle damage
- MeSH
- muscle, skeletal, humans, alanine transaminase, aspartate aminotransferases, vitamin d, serum albumin, interleukin-4, exercise, analysis of variance, linear models, recovery of function, muscle fatigue, isometric contraction, time factors, adult, utah, female, male, muscle strength, interferon-gamma, biomarkers, serum albumin, human
8 autores
- Tyler Barker🇺🇸 · autor de correspondenciaOrthopedic Specialty Hospital
- Vanessa T. Henriksen🇺🇸Orthopedic Specialty Hospital
- Thomas B. Martins🇺🇸ARUP Institute for Clinical and Experimental Pathology; ARUP Laboratories (United States)
- Harry R. Hill🇺🇸University of Utah; ARUP Institute for Clinical and Experimental Pathology; ARUP Laboratories (United States)
- Carl R. Kjeldsberg🇺🇸University of Utah; ARUP Institute for Clinical and Experimental Pathology; ARUP Laboratories (United States)
- Erik D. Schneider🇺🇸USANA Health Sciences, Inc. (United States)
- Brian Dixon🇺🇸USANA Health Sciences, Inc. (United States)
- Lindell K. Weaver🇺🇸University of Utah; LDS Hospital; Intermountain Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
The primary purpose of this study was to identify if serum 25-hydroxyvitamin D (25(OH)D) concentrations predict muscular weakness after intense exercise. We hypothesized that pre-exercise serum 25(OH)D concentrations inversely predict exercise-induced muscular weakness. Fourteen recreationally active adults participated in this study. Each subject had one leg randomly assigned as a control. The other leg performed an intense exercise protocol. Single-leg peak isometric force and blood 25(OH)D, aspartate and alanine aminotransferases, albumin, interferon (IFN)-γ, and interleukin-4 were measured prior to and following intense exercise. Following exercise, serum 25(OH)D concentrations increased (p < 0.05) immediately, but within minutes, subsequently decreased (p < 0.05). Circulating albumin increases predicted (p < 0.005) serum 25(OH)D increases, while IFN-γ increases predicted (p < 0.001) serum 25(OH)D decreases. Muscular weakness persisted within the exercise leg (p < 0.05) and compared to the control leg (p < 0.05) after the exercise protocol. Serum 25(OH)D concentrations inversely predicted (p < 0.05) muscular weakness (i.e., control leg vs. exercise leg peak isometric force) immediately and days (i.e., 48-h and 72-h) after exercise, suggesting the attenuation of exercise-induced muscular weakness with increasing serum 25(OH)D prior to exercise. Based on these data, we conclude that pre-exercise serum 25(OH)D concentrations could influence the recovery of skeletal muscle strength after an acute bout of intense exercise.
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