Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial
Jones ML, Martoni CJ, Prakash S
The Journal of clinical endocrinology and metabolism · 146 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- McGill University
- Universidad u hospital
- Faculty of Medicine, McGill University
Según 2 financiadores declarados.
Publicación
- Publicado
- 2013-04-23 · J Clin Endocrinol Metab · vol. 98 · número 7 · págs. 2944–2951
- Editorial
- Oxford University Press
- Citado
- 195 citas · más que el 97% de estudios similares · 8.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Probiotics and Fermented Foods · Vitamin D Research Studies · Antioxidant Activity and Oxidative Stress
- Palabras clave
- probiotic supplementation, 25-hydroxyvitamin D, vitamin D, bile salt hydrolase, hypercholesterolemia, cholesterol-lowering therapy, fat-soluble vitamins, vitamin A, vitamin E, beta-carotene, dietary intake
- MeSH
- humans, hypercholesterolemia, vitamin d deficiency, calcifediol, 25-hydroxyvitamin d 2, amidohydrolases, vitamin d, bacterial proteins, anticholesteremic agents, double-blind method, intestinal absorption, probiotics, adult, aged, middle aged, czech republic, female, male, cholesterol, ldl, young adult, limosilactobacillus reuteri
3 autores
- Mitchell Lawrence Jones🇨🇦Micropharma (Canada); McGill University
- Christopher Martoni🇨🇦Micropharma (Canada)
- Satya Prakash🇨🇦 · autor de correspondenciaMicropharma (Canada); McGill University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Low serum 25-hydroxyvitamin D is a risk factor for osteoporosis, cardiovascular disease, diabetes, and cancer. Disruption of noncholesterol sterol absorption due to cholesterol-lowering therapies may result in reduced fat-soluble vitamin absorption.
Objective
We have previously reported on the cholesterol-lowering efficacy and reduced sterol absorption of probiotic bile salt hydrolase active Lactobacillus reuteri NCIMB 30242; however, the effects on fat-soluble vitamins was previously unknown and the objective of the present study. DESIGN, SETTINGS, PATIENTS, AND INTERVENTION: The study was double-blind, placebo-controlled, randomized, parallel-arm, multicenter lasting 13 weeks. A total of 127 otherwise healthy hypercholesterolemic adults with low-density lipoprotein-cholesterol >3.4 mmol/L, triglycerides <4.0 mmol/L, and body mass index of 22 to 32 kg/m² were included. Subjects were recruited from 6 private practices in Prague, Czech Republic, and randomized to consume L. reuteri NCIMB 30242 or placebo capsules over a 9-week intervention period.
Outcome measures
The primary outcome measure was the change in serum low-density lipoprotein-cholesterol over the 9-week intervention. Analysis of fat-soluble vitamins at weeks 0 and 9 were performed post hoc.
Results
There were no significant differences between L. reuteri NCIMB 30242 and placebo capsule groups in serum vitamin A, vitamin E, or β-carotene or dietary intake over the intervention period (P > .05). L. reuteri NCIMB 30242 increased serum 25-hydroxyvitamin D by 14.9 nmol/L, or 25.5%, over the intervention period, which was a significant mean change relative to placebo of 17.1 nmol/L, or 22.4%, respectively (P = .003).
Conclusions
To our knowledge, this is the first report of increased circulating 25-hydroxyvitamin D in response to oral probiotic supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.