Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies
Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, Hu FB
Diabetes care · 376 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (U34-DK-91958); National Cancer Institute (U01CA138962); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK058845); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076092); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK76092); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK088078); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK58845); National Institute of Diabetes and Digestive and Kidney Diseases (U34DK091958); National Cancer Institute (R01CA138962)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-04-13 · Diabetes Care · vol. 36 · número 5 · págs. 1422–1428
- Editorial
- American Diabetes Association
- Citado
- 510 citas · más que el 100% de estudios similares · 32.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- 25-hydroxyvitamin D, vitamin D, type 2 diabetes, incident diabetes risk, dose-response relationship, circulating vitamin D levels, inverse association
- MeSH
- humans, diabetes mellitus, type 2, vitamin d, risk factors, prospective studies
7 autores
- Yiqing Song🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- Lu Wang🇺🇸Brigham and Women's Hospital; Harvard University
- Anastassios G. Pittas🇺🇸Tufts Medical Center
- Liana C. Del Gobbo🇺🇸Harvard University
- Cuilin Zhang🇺🇸National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes.
Research design and methods
A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird's random-effects model was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation.
Results
A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95% CI 0.54-0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4% lower risk of type 2 diabetes (95% CI 3-6; P for linear trend < 0.0001).
Conclusions
Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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