Long-term alcohol and caffeine intake and risk of sudden cardiac death in women
Bertoia ML, Triche EW, Michaud DS, Baylin A, Hogan JW, Neuhouser ML, Freiberg MS, Allison MA, Safford MM, Li W, Mossavar-Rahmani Y, Rosal MC, Eaton CB
The American journal of clinical nutrition · 25 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- U.S. Public Health Service
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- PHS HHS
- Gobierno
- WHI NIH HHS
- Gobierno
- NICHD NIH HHS
- Subvenciones
- U.S. Public Health Service (44221); U.S. Public Health Service (32122); U.S. Public Health Service (24152); U.S. Public Health Service (42107-26); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24-HD041020); U.S. Public Health Service (42129-32); U.S. Public Health Service (32118-32119); U.S. Public Health Service (32100-2); U.S. Public Health Service (32105-6); National Institutes of Health (N01-WH-2-2110); U.S. Public Health Service (32108-9); U.S. Public Health Service (32111-13); U.S. Public Health Service (32115)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2013-04-25 · Am J Clin Nutr · vol. 97 · número 6 · págs. 1356–1363
- Editorial
- Elsevier BV
- Citado
- 38 citas · más que el 90% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Alcohol Consumption and Health Effects · Coffee research and impacts · Cardiac electrophysiology and arrhythmias
- Palabras clave
- sudden cardiac death, alcohol consumption, caffeine consumption, coffee consumption, tea consumption, postmenopausal women, cardiovascular risk factors, time-varying exposure, Women's Health Initiative
- MeSH
- humans, death, sudden, cardiac, caffeine, body mass index, risk factors, alcohol drinking, smoking, postmenopause, socioeconomic factors, coffee, tea, aged, middle aged, female, surveys and questionnaires
13 autores
- Monica L. Bertoia🇺🇸Brown University
- Elizabeth Westerlund Triche🇺🇸Brown University
- Dominique S. Michaud🇺🇸Brown University
- Ana Baylín🇺🇸University of Michigan
- Joseph W. Hogan🇺🇸Brown University
- Marian L. Neuhouser🇺🇸Fred Hutch Cancer Center
- Matthew S. Freiberg🇺🇸University of Pittsburgh
- Matthew Allison🇺🇸University of California San Diego
- Monika M. Safford🇺🇸University of Alabama at Birmingham
- Wenjun Li🇺🇸University of Massachusetts Chan Medical School
- Yasmin Mossavar‐Rahmani
- Milagros C. Rosal🇺🇸University of Massachusetts Chan Medical School
- Charles B. Eaton🇺🇸Brown University; Memorial Hospital of Rhode Island
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Alcohol and caffeine intakes may play a role in the development of sudden cardiac death (SCD) because of their effects on cholesterol, blood pressure, heart rate variability, and inflammation.
Objective
Our objective was to examine the association between long-term alcohol and caffeine intakes and risk of SCD in women.
Design
We examined 93,676 postmenopausal women who participated in the Women's Health Initiative Observational Study. Women were enrolled between 1993 and 1998 and were followed until August 2009. Women completed a food-frequency questionnaire at baseline and again at year 3. We modeled exposure to alcohol 3 ways: by using baseline intake only, a cumulative average of baseline and year 3 intake, and the most recent reported intake (a simple time-varying analysis).
Results
Intake of 5-15 g alcohol/d (about one drink) was associated with a nonsignificantly reduced risk of SCD compared with 0.1-5 g/d of baseline intake (HR: 0.64; 95% CI: 0.40, 1.02), of cumulative average intake (HR: 0.69; 95% CI: 0.43, 1.11), and of most recent intake (HR: 0.58; 95% CI: 0.35, 0.96), with adjustment for age, race, income, smoking, body mass index, physical activity, hormone use, and total energy. No association was found between SCD and total caffeine intake (mg/d) or cups of caffeinated coffee, decaffeinated coffee, and caffeinated tea.
Conclusions
Our results suggest that about one drink per day (or 5.1-15 g/d) may be associated with a reduced risk of SCD in this population; however, this association was only statistically significant for a model using the most recent alcohol intake. Total caffeine, regular coffee, decaffeinated coffee, and regular tea intake were not associated with the risk of SCD. This trial was registered at clinicaltrials.gov as NCT00000611.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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