A whole-grain-rich diet reduces urinary excretion of markers of protein catabolism and gut microbiota metabolism in healthy men after one week
Ross AB, Pere-Trépat E, Montoliu I, Martin FP, Collino S, Moco S, Godin JP, Cléroux M, Guy PA, Breton I, Bibiloni R, Thorimbert A, Tavazzi I, Tornier L, Bebuis A, Bruce SJ, Beaumont M, Fay LB, Kochhar S
The Journal of nutrition · 37 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2013-04-25 · J Nutr · vol. 143 · número 6 · págs. 766–773
- Editorial
- Elsevier BV
- Citado
- 48 citas · más que el 95% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Gut microbiota and health
- Palabras clave
- whole grain diet, refined grains, protein degradation, urinary metabolites, gut microbiota metabolism, urea, L-carnitine, acylcarnitines, short-chain fatty acids, acetate, butyrate, plasma metabolites, fecal water, metabolite profiling
- MeSH
- intestines, feces, humans, bacteria, methylguanidine, methylamines, acetates, phenylacetates, urea, nicotinic acids, carnitine, proteins, magnetic resonance spectroscopy, diet, cross-over studies, sex factors, energy metabolism, food handling, dietary fiber, adult, middle aged, health promotion, female, male, lipid metabolism, gas chromatography-mass spectrometry, metabolome, organophosphates, biomarkers, edible grain
19 autores
- Alastair B. Ross🇨🇭 · autor de correspondenciaNestlé (Switzerland)
- Emma Peré‐Trepat🇨🇭Nestlé (Switzerland)
- Ivan Montoliu🇨🇭Nestlé (Switzerland)
- François‐Pierre Martin🇨🇭Nestlé (Switzerland)
- Sebastiano Collino🇨🇭Nestlé (Switzerland)
- Sofia Moco🇨🇭Nestlé (Switzerland)
- Jean‐Philippe Godin🇨🇭Nestlé (Switzerland)
- Marilyn Cléroux🇨🇭Nestlé (Switzerland)
- Philippe A. Guy🇨🇭Nestlé (Switzerland)
- Isabelle Breton🇨🇭Nestlé (Switzerland)
- Rodrigo Bibiloni🇨🇭Nestlé (Switzerland)
- Anita Thorimbert🇨🇭Nestlé (Switzerland)
- Isabelle Tavazzi🇨🇭Nestlé (Switzerland)
- Lionel Tornier🇨🇭Nestlé (Switzerland)
- Aude Bebuis🇨🇭Nestlé (Switzerland)
- Stephen J. Bruce🇨🇭Nestlé (Switzerland)
- Maurice Beaumont🇨🇭Nestlé (Switzerland)
- Laurent‐Bernard Fay🇨🇭Nestlé (Switzerland)
- Sunil Kochhar🇨🇭Nestlé (Switzerland)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may be beneficial for health remain speculative. In an exploratory, randomized, researcher-blinded, crossover trial, we measured metabolic profile differences between healthy participants eating a diet based on WGs compared with a diet based on RGs. Seventeen healthy adult participants (11 female, 6 male) consumed a controlled diet based on either WG-rich or RG-rich foods for 2 wk, followed by the other diet after a 5-wk washout period. Both diets were the same except for the use of WG (150 g/d) or RG foods. The metabolic profiles of plasma, urine, and fecal water were measured using (1)H-nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry (plasma only). After 1 wk of intervention, the WG diet led to decreases in urinary excretion of metabolites related to protein catabolism (urea, methylguanadine), lipid (carnitine and acylcarnitines) and gut microbial (4-hydroxyphenylacetate, trimethylacetate, dimethylacetate) metabolism in men compared with the same time point during the RG intervention. There were no differences between the interventions after 2 wk. Urinary urea, carnitine, and acylcarnitine were lower at wk 1 of the WG intervention relative to the RG intervention in all participants. Fecal water short-chain fatty acids acetate and butyrate were relatively greater after the WG diet compared to the RG diet. Although based on a small population and for a short time period, these observations suggest that a WG diet may affect protein metabolism.
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