Serum 25-hydroxyvitamin D levels and the risk of depression: a systematic review and meta-analysis
Ju SY, Lee YJ, Jeong SN
The journal of nutrition, health & aging · 117 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2012-12-02 · J Nutr Health Aging · vol. 17 · número 5 · págs. 447–455
- Editorial
- Springer Science+Business Media
- Citado
- 147 citas · más que el 76% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · Mental Health Treatment and Access · Treatment of Major Depression
- Palabras clave
- 25-hydroxyvitamin D, vitamin D, depression, serum vitamin D levels, depression risk, dose-response relationship, older adults, vitamin D deficiency
- MeSH
- humans, vitamin d deficiency, vitamin d, depression, depressive disorder
3 autores
- Sang-Yhun Ju🇰🇷 · autor de correspondenciaThe Catholic University of Korea Yeouido St. Mary's Hospital; Catholic University of Korea
- Youn Joo Lee🇰🇷The Catholic University of Korea Seoul St. Mary's Hospital; Catholic University of Korea
- S.-N. Jeong🇰🇷Sookmyung Women's University; The Catholic University of Korea Yeouido St. Mary's Hospital; Catholic University of Korea
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
No quantitative systematic review or meta-analysis of population-based epidemiological studies has been conducted to assess the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of depression. This study aimed to summarize the current evidence from cross-sectional and prospective cohort studies that have evaluated the association between 25(OH)D levels and the risk of depression.
Methods
Relevant studies were identified by systematically searching the PubMed, EMBASE, Web of Science, and PsycINFO databases through April 2012. Cross-sectional and cohort studies that reported adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association of interest were included. The reported risk estimates for 25(OH)D categories were recalculated, employing a comprehensive trend estimation from summarized dose-response data. A pooled OR was calculated separately for cross-sectional and cohort studies using random-effects models.
Results
In the meta-analysis, 25(OH)D levels were significantly inversely associated with depression in 5 of 11 case-control studies and 2 of 5 cohort studies. The pooled estimate of the adjusted OR of depression in 11 cross-sectional studies (n = 43,137) was 0.96 (95% CI = 0.94-0.99, I2 = 63%) for a 10 ng/ml increase in 25(OH)D levels. The 5 included cohort studies comprised 12,648 participants, primarily elderly individuals, whose serum 25(OH)D levels were measured, and 2,663 experienced depression events during follow-up. The pooled adjusted OR of depression was 0.92 (95% CI = 0.87-0.98, I2 = 50%) for a 10 ng/ml increase in 25(OH)D levels.
Conclusions
Our results indicate an inverse association between serum 25(OH)D levels and the risk of depression. Further studies are warranted to establish whether this association is causal.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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