Magnesium supplementation to prevent high blood pressure in pregnancy: a randomised placebo control trial
Bullarbo M, Ödman N, Nestler A, Nielsen T, Kolisek M, Vormann J, Rylander R
Archives of gynecology and obstetrics · 13 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-05-29 · Arch Gynecol Obstet · vol. 288 · número 6 · págs. 1269–1274
- Editorial
- Springer Science+Business Media
- Citado
- 37 citas · más que el 91% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Pregnancy and preeclampsia studies · Magnesium in Health and Disease · Blood Pressure and Hypertension Studies
- Palabras clave
- magnesium supplementation, magnesium citrate, hypertension in pregnancy, gestational hypertension, blood pressure regulation, urinary magnesium excretion, primigravida, prenatal care, pregnancy outcomes
- MeSH
- humans, hypertension, calcium, citric acid, organometallic compounds, pregnancy outcome, treatment outcome, administration, oral, double-blind method, pregnancy, pregnancy trimester, second, pregnancy trimester, third, blood pressure, socioeconomic factors, adult, sweden, female
7 autores
- Maria Bullarbo🇸🇪University of Gothenburg
- Natalia Ödman🇸🇪Södra Älvsborg Hospital; University of Gothenburg
- Axel Nestler🇩🇪Freie Universität Berlin
- Thorkild F. Nielsen🇸🇪Södra Älvsborg Hospital; University of Gothenburg
- Martin Kolísek🇩🇪Freie Universität Berlin
- Jürgen Vormann
- Ragnar Rylander🇸🇪 · autor de correspondenciaBioFact Environmental Health Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To assess if hypertension during the last part of pregnancy could be prevented by magnesium supplementation.
Methods
Pregnant primagravida women from a local antenatal care unit were given an oral supply of 300 mg magnesium as citrate or placebo from pregnancy week 25 in a randomised double-blind setup. Blood pressure was recorded during pregnancy as well as pregnancy outcome.
Results
In the magnesium-supplemented group, the average diastolic blood pressure at week 37 was significantly lower than in the placebo group (72/1.4 mean/SEM vs 77/1.4, p = 0.031). The number of women with an increase in diastolic blood pressure of ≥15 mmHg was significantly lower in the magnesium group compared with the women who received placebo (p = 0.011). There was an inverse relation between the urinary excretion of magnesium during pregnancy and the diastolic blood pressure (p = 0.005).
Conclusions
Magnesium supplementation prevented an increase in diastolic blood pressure during the last weeks of pregnancy. The relation between diastolic blood pressure and urinary excretion of magnesium suggests that magnesium is involved in the regulation of blood pressure and that the increase in diastolic blood pressure in pregnancy could be due to a lack of magnesium.
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