Financiado en parte por Biogen, Teva Pharmaceutical Industries
Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial
Martínez-Lapiscina EH, Clavero P, Toledo E, San Julián B, Sanchez-Tainta A, Corella D, Lamuela-Raventós RM, Martínez JA, Martínez-Gonzalez MÁ
The journal of nutrition, health & aging · 192 citas
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Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Biogen
- Empresa
- Teva Pharmaceutical Industries
- Gobierno
- Instituto de Salud Carlos III
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-03-17 · J Nutr Health Aging · vol. 17 · número 6 · págs. 544–552
- Editorial
- Springer Science+Business Media
- Citado
- 267 citas · más que el 100% de estudios similares · 21.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 83 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nutritional Studies and Diet · Nuts composition and effects · Diet and metabolism studies
- Palabras clave
- Mediterranean diet, Medicine, Randomized controlled trial, Cognition, Cognitive decline, Body mass index, Dementia, Gerontology, Type 2 diabetes, Physical therapy, Diabetes mellitus, Internal medicine, Psychiatry, Endocrinology, Disease
- MeSH
- humans, nuts, dementia, plant oils, body mass index, treatment outcome, diet, fat-restricted, nutrition assessment, multivariate analysis, logistic models, follow-up studies, feeding behavior, patient compliance, motor activity, cognition, diet, mediterranean, energy intake, dietary supplements, aged, aged, 80 and over, middle aged, female, male, olive oil, surveys and questionnaires, cognitive dysfunction
9 autores
- Elena Hernandez Martinez-Lapiscina🇪🇸 · autor de correspondenciaClinica Universidad de Navarra; Universidad de Navarra
- Pedro Clavero🇪🇸Complejo Hospitalario de Navarra
- Estefanía Toledo🇪🇸Instituto de Salud Carlos III; Universidad de Navarra
- Bao-Quyn Julian🇪🇸Universidad de Navarra
- Ana Sánchez‐Tainta🇪🇸Universidad de Navarra
- Dolores Corella🇪🇸Universitat de València; Instituto de Salud Carlos III
- Rosa Maria Lamuela-Raventós🇪🇸Instituto de Salud Carlos III; Universitat de Barcelona
- J. Alfredo Martínéz🇪🇸Instituto de Salud Carlos III; Universidad de Navarra
- Miguel Ángel Martínez‐González🇪🇸Instituto de Salud Carlos III; Universidad de Navarra
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet).
Design
Randomized trial after 6.5 years of nutritional intervention.
Setting
Eight primary care centers affiliated to the University of Navarra.
Participants
A random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All of them were at high vascular risk (44.8% men, 74.1±5.7 years at cognitive evaluation).
Interventions
Nutritional intervention comparing two MedDiets (supplemented with extra-virgin olive oil [EVOO] or mixed nuts) versus a low-fat control diet. Participants received intensive education to increase adherence to the intended intervention. Participants allocated to the MedDiet groups received EVOO (1 l/week) or 30 g/day of mixed nuts. Dietary habits were evaluated using a validated 137-item food frequency questionnaire (FFQ). Additionally, adherence to MedDiet was appraised using a 14-item questionnaire both at baseline and yearly thereafter.
Measurements
Cognitive performance as a main outcome and cognitive status (normal, mild cognitive impairment [MCI] or dementia) as a secondary outcome were evaluated by two neurologists blinded to group assignment after 6.5 years of nutritional intervention.
Results
Better post-trial cognitive performance versus control in all cognitive domains and significantly better performance across fluency and memory tasks were observed for participants allocated to the MedDiet+EVOO group. After adjustment for sex, age, education, apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass index, hypertension, dyslipidaemia, diabetes, alcohol and total energy intake, this group also showed lower MCI (OR=0.34 95% CI: 0.12-0.97) compared with control group. Participants assigned to MedDiet+Nuts group did not differ from controls.
Conclusion
A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. However, non-significant differences were found for most cognitive domains. Participants allocated to an EVOO-rich MedDiet had less MCI than controls.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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