Creatine for treating muscle disorders
Kley RA, Tarnopolsky MA, Vorgerd M
The Cochrane database of systematic reviews · 50 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- World Health Organization
Según 1 financiador declarado.
Publicación
- Publicado
- 2013-06-05 · Cochrane Database Syst Rev · vol. 2013 · número 6 · pág. CD004760
- Editorial
- Elsevier BV
- Citado
- 160 citas · más que el 98% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 109 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Nutrition and Health in Aging
- Palabras clave
- muscle weakness, myopathy, muscular dystrophy, idiopathic inflammatory myopathies, metabolic myopathies, muscle strength, functional performance, activities of daily living, neuromuscular disorders, treatment efficacy, adverse events, placebo comparison, hereditary muscle disease, myalgia, muscle fatigue, muscle cramps
- MeSH
- humans, muscular diseases, muscular dystrophies, myositis, creatine, muscle contraction, dietary supplements, muscle strength, randomized controlled trials as topic
3 autores
- Rudolf Andre Kley🇩🇪BG University Hospital Bergmannsheil Bochum; Ruhr University Bochum
- Mark Andrew Tarnopolsky🇨🇦McMaster University
- Matthias Vorgerd🇩🇪BG University Hospital Bergmannsheil Bochum; Ruhr University Bochum
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Progressive muscle weakness is a main symptom of most hereditary and acquired muscle diseases. Creatine improves muscle performance in healthy individuals. This is an update of our 2007 Cochrane review that evaluated creatine treatment in muscle disorders. Previous updates were in 2009 and 2011.
Objectives
To evaluate the efficacy of creatine compared to placebo for the treatment of muscle weakness in muscle diseases.
Search methods
On 11 September 2012, we searched the Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL (2012, Issue 9 in The Cochrane Library), MEDLINE (January 1966 to September 2012) and EMBASE (January 1980 to September 2012) for randomised controlled trials (RCTs) of creatine used to treat muscle diseases.
Selection criteria
RCTs or quasi-RCTs of creatine treatment compared to placebo in hereditary muscle diseases or idiopathic inflammatory myopathies.
Data collection and analysis
Two authors independently applied the selection criteria, assessed trial quality and extracted data. We obtained missing data from investigators.
Main results
A total of 14 trials, including 364 randomised participants, met the selection criteria. The risk of bias was low in most studies. Only one trial had a high risk of selection, performance and detection bias. No new studies were identified at this update.Meta-analysis of six trials in muscular dystrophies including 192 participants revealed a significant increase in muscle strength in the creatine group compared to placebo, with a mean difference of 8.47%; (95% confidence intervals (CI) 3.55 to 13.38). Pooled data of four trials including 115 participants showed that a significantly higher number of participants felt better during creatine treatment compared to placebo with a risk ratio of 4.51 (95% CI 2.33 to 8.74). One trial in 37 participants with idiopathic inflammatory myopathies also showed a significant improvement in functional performance. No trial reported any clinically relevant adverse event.In metabolic myopathies, meta-analyses of three cross-over trials including 33 participants revealed no significant difference in muscle strength. One trial reported a significant deterioration of activities of daily living (mean difference 0.54 on a 1 to 10 scale; 95% CI 0.14 to 0.93) and an increase in muscle pain during high-dose creatine treatment in McArdle disease.
Authors' conclusions
High quality evidence from RCTs shows that short- and medium-term creatine treatment increases muscle strength in muscular dystrophies. There is also evidence that creatine improves functional performance in muscular dystrophy and idiopathic inflammatory myopathy. Creatine is well tolerated in these people. High quality but limited evidence from RCTs does not show significant improvement in muscle strength in metabolic myopathies. High-dose creatine treatment impaired activities of daily living and increased muscle pain in McArdle disease.
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